Titre
Antidote treatment for cyanide poisoning with hydroxocobalamin causes bright pink discolouration and chemical-analytical interferences.
Type
étude de cas
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Périodique
Auteur(s)
Brunel, C.
Auteure/Auteur
Widmer, C.
Auteure/Auteur
Augsburger, M.
Auteure/Auteur
Dussy, F.
Auteure/Auteur
Fracasso, T.
Auteure/Auteur
Liens vers les personnes
Liens vers les unités
ISSN
1872-6283
Statut éditorial
Publié
Date de publication
2012
Volume
223
Numéro
1-3
Première page
e10
Dernière page/numéro d’article
e12
Langue
anglais
Notes
Publication types: Journal ArticlePublication Status: ppublish
Résumé
Here we report the case of a 70-year-old woman who committed suicide by cyanide poisoning. During resuscitation cares, she underwent an antidote treatment by hydroxocobalamin. Postmortem investigations showed marked bright pink discolouration of organs and fluids, and a lethal cyanide blood concentration of 43 mg/L was detected by toxicological investigation. Discolouration of hypostasis and organs has widely been studied in forensic literature. In our case, we interpreted the unusual pink coloration as the result of the presence of hydroxocobalamin. This substance is a known antidote against cyanide poisoning, indicated because of its efficiency and poor adverse effects. However, its main drawback is to interfere with measurements of many routine biochemical parameters. We have tested the potential influence of this molecule in some routine postmortem investigations. The results are discussed.
PID Serval
serval:BIB_D957915C6196
PMID
Date de création
2013-03-22T13:49:16.159Z
Date de création dans IRIS
2025-05-21T00:57:14Z