Titre
The Neurocognitive Assessment in the Metabolic and Aging Cohort (NAMACO) study: baseline participant profile.
Type
article
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Périodique
Auteur(s)
Métral, M.
Co-première auteure/Co-premier auteur
Darling, K.
Co-première auteure/Co-premier auteur
Locatelli, I.
Auteure/Auteur
Nadin, I.
Auteure/Auteur
Santos, G.
Auteure/Auteur
Brugger, P.
Auteure/Auteur
Kovari, H.
Auteure/Auteur
Cusini, A.
Auteure/Auteur
Gutbrod, K.
Auteure/Auteur
Tarr, P.E.
Auteure/Auteur
Calmy, A.
Auteure/Auteur
Lecompte, T.D.
Auteure/Auteur
Assal, F.
Auteure/Auteur
Monsch, A.
Auteure/Auteur
Kunze, U.
Auteure/Auteur
Stoeckle, M.
Auteure/Auteur
Schwind, M.
Auteure/Auteur
Schmid, P.
Auteure/Auteur
Pignatti, R.
Auteure/Auteur
Di Benedetto, C.
Auteure/Auteur
Du Pasquier, R.
Auteure/Auteur
Cavassini, M.
Auteure/Auteur
Contributrices/contributeurs
Cavassini, M.
Du Pasquier, R.
Métral, M.
Simioni, S.
Brugger, P.
Gutbrod, K.
Monsch, A.U.
Kunze, U.
Schneitter, M.
Nadin, I.
Früh, S.
Schwind, M.
Pignatti, R.
Clarke, S.
Assal, F.
Derfuss, T.
von Arx, S.
Eisele, G.
Sacco, L.
Bertschi, M.
Hundsberger, T.
Du Pasquier, R.
Calmy, A.
Lecompte, T.D.
Hauser, C.
Cusini, A.
Weber, R.
Kovari, H.
Hasse, B.
Tarr, P.
Stoeckle, M.
Fux, C.
Bernasconi, E.
Di Benedetto, C.
Bruno, A.
Schmid, P.
Darling, K.
Cavassini, M.
Scherrer, A.
Scherrer, A.
Vallet, Y.
Alves, D.
Locatelli, I.
Decosterd, L.
Granziera, C.
Krueger, G.
Meuli, R.
Vargas, M.
Groupes de travail
NAMACO study group
Swiss HIV Cohort Study
Liens vers les personnes
Liens vers les unités
ISSN
1468-1293
Statut éditorial
Publié
Date de publication
2020-01
Volume
21
Numéro
1
Première page
30
Dernière page/numéro d’article
42
Peer-reviewed
Oui
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Publication Status: ppublish
Résumé
The aim of the study was to examine baseline neurocognitive impairment (NCI) prevalence and factors associated with NCI among patients enrolled in the Neurocognitive Assessment in the Metabolic and Aging Cohort (NAMACO) study.
The NAMACO study is an ongoing, prospective, longitudinal, multicentre and multilingual (German, French and Italian) study within the Swiss HIV Cohort Study. Between 1 May 2013 and 30 November 2016, 981 patients ≥ 45 years old were enrolled in the study. All underwent standardized neuropsychological (NP) assessment by neuropsychologists. NCI was diagnosed using Frascati criteria and classified as HIV-associated or as related to other factors. Dichotomized analysis (NCI versus no NCI) and continuous analyses (based on NP test z-score means) were performed.
Most patients (942; 96.2%) had viral loads < 50 HIV-1 RNA copies/mL. NCI was identified in 390 patients (39.8%): 263 patients (26.8%) had HIV-associated NCI [249 patients (25.4%) had asymptomatic neurocognitive impairment (ANI)] and 127 patients (13%) had NCI attributable to other factors, mainly psychiatric disorders. There was good correlation between dichotomized and continuous analyses, with NCI associated with older age, non-Caucasian ethnicity, shorter duration of education, unemployment and longer antiretroviral therapy duration.
In this large sample of aging people living with HIV with well-controlled infection in Switzerland, baseline HIV-associated NCI prevalence, as diagnosed after formal NP assessment, was 26.8%, with most cases being ANI. The NAMACO study data will enable longitudinal analyses within this population to examine factors affecting NCI development and course.
The NAMACO study is an ongoing, prospective, longitudinal, multicentre and multilingual (German, French and Italian) study within the Swiss HIV Cohort Study. Between 1 May 2013 and 30 November 2016, 981 patients ≥ 45 years old were enrolled in the study. All underwent standardized neuropsychological (NP) assessment by neuropsychologists. NCI was diagnosed using Frascati criteria and classified as HIV-associated or as related to other factors. Dichotomized analysis (NCI versus no NCI) and continuous analyses (based on NP test z-score means) were performed.
Most patients (942; 96.2%) had viral loads < 50 HIV-1 RNA copies/mL. NCI was identified in 390 patients (39.8%): 263 patients (26.8%) had HIV-associated NCI [249 patients (25.4%) had asymptomatic neurocognitive impairment (ANI)] and 127 patients (13%) had NCI attributable to other factors, mainly psychiatric disorders. There was good correlation between dichotomized and continuous analyses, with NCI associated with older age, non-Caucasian ethnicity, shorter duration of education, unemployment and longer antiretroviral therapy duration.
In this large sample of aging people living with HIV with well-controlled infection in Switzerland, baseline HIV-associated NCI prevalence, as diagnosed after formal NP assessment, was 26.8%, with most cases being ANI. The NAMACO study data will enable longitudinal analyses within this population to examine factors affecting NCI development and course.
PID Serval
serval:BIB_78CE4480FCE1
PMID
Open Access
Oui
Date de création
2019-10-08T20:00:05.635Z
Date de création dans IRIS
2025-05-20T22:01:47Z
Fichier(s)![Vignette d'image]()
En cours de chargement...
Nom
HIV-21-30.pdf
Version du manuscrit
published
Licence
https://creativecommons.org/licenses/by-nc-nd/4.0
Taille
241.01 KB
Format
Adobe PDF
PID Serval
serval:BIB_78CE4480FCE1.P001
URN
urn:nbn:ch:serval-BIB_78CE4480FCE10
Somme de contrôle
(MD5):b3a6cb1481929c4386daac8ad4d07f2b