Titre
A historical legacy of antibiotic utilization on bacterial seed banks in sediments.
Type
article
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Périodique
Auteur(s)
Madueño, L.
Auteure/Auteur
Paul, C.
Auteure/Auteur
Junier, T.
Auteure/Auteur
Bayrychenko, Z.
Auteure/Auteur
Filippidou, S.
Auteure/Auteur
Beck, K.
Auteure/Auteur
Greub, G.
Auteure/Auteur
Bürgmann, H.
Auteure/Auteur
Junier, P.
Auteure/Auteur
Liens vers les personnes
Liens vers les unités
ISSN
2167-8359
Statut éditorial
Publié
Date de publication
2018
Volume
6
Première page
e4197
Peer-reviewed
Oui
Langue
anglais
Résumé
The introduction of antibiotics for both medical and non-medical purposes has had a positive effect on human welfare and agricultural output in the past century. However, there is also an important ecological legacy regarding the use of antibiotics and the consequences of increased levels of these compounds in the environment as a consequence of their use and disposal. This legacy was investigated by quantifying two antibiotic resistance genes (ARG) conferring resistance to tetracycline (tet(W)) and sulfonamide (sul1) in bacterial seed bank DNA in sediments. The industrial introduction of antibiotics caused an abrupt increase in the total abundance of tet(W) and a steady increase in sul1. The abrupt change in tet(W) corresponded to an increase in relative abundance from ca. 1960 that peaked around 1976. This pattern of accumulation was highly correlated with the abundance of specific members of the seed bank community belonging to the phylum Firmicutes. In contrast, the relative abundance of sul1 increased after 1976. This correlated with a taxonomically broad spectrum of bacteria, reflecting sul1 dissemination through horizontal gene transfer. The accumulation patterns of both ARGs correspond broadly to the temporal scale of medical antibiotic use. Our results show that the bacterial seed bank can be used to look back at the historical usage of antibiotics and resistance prevalence.
PID Serval
serval:BIB_ABD7157C5495
PMID
Open Access
Oui
Date de création
2018-01-22T10:02:33.749Z
Date de création dans IRIS
2025-05-20T22:37:36Z
Fichier(s)![Vignette d'image]()
En cours de chargement...
Nom
peerj-4197.pdf
Version du manuscrit
published
Taille
3.87 MB
Format
Adobe PDF
PID Serval
serval:BIB_ABD7157C5495.P001
URN
urn:nbn:ch:serval-BIB_ABD7157C54955
Somme de contrôle
(MD5):285ac84c99942e6217f53876e9ab2b46