Titre
Molecular biomarkers in the context of focal therapy for prostate cancer: recommendations of a Delphi Consensus from the Focal Therapy Society.
Type
article
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Périodique
Auteur(s)
Marra, G.
Auteure/Auteur
Laguna, M.P.
Auteure/Auteur
Walz, J.
Auteure/Auteur
Pavlovich, C.P.
Auteure/Auteur
Bianco, F.
Auteure/Auteur
Gregg, J.
Auteure/Auteur
Lebastchi, A.H.
Auteure/Auteur
Lepor, H.
Auteure/Auteur
Macek, P.
Auteure/Auteur
Rais-Bahrami, S.
Auteure/Auteur
Robertson, C.
Auteure/Auteur
Rukstalis, D.
Auteure/Auteur
Salomon, G.
Auteure/Auteur
Ukimura, O.
Auteure/Auteur
Abreu, A.L.
Auteure/Auteur
Barbe, Y.
Auteure/Auteur
Cathelineau, X.
Auteure/Auteur
Gandaglia, G.
Auteure/Auteur
George, A.K.
Auteure/Auteur
Gomez Rivas, J.
Auteure/Auteur
Gupta, R.T.
Auteure/Auteur
Lawrentschuk, N.
Auteure/Auteur
Kasivisvanathan, V.
Auteure/Auteur
Lomas, D.
Auteure/Auteur
Malavaud, B.
Auteure/Auteur
Margolis, D.
Auteure/Auteur
Matsuoka, Y.
Auteure/Auteur
Mehralivand, S.
Auteure/Auteur
Moschini, M.
Auteure/Auteur
Oderda, M.
Auteure/Auteur
Orabi, H.
Auteure/Auteur
Rastinehad, A.R.
Auteure/Auteur
Remzi, M.
Auteure/Auteur
Schulman, A.
Auteure/Auteur
Shin, T.
Auteure/Auteur
Shiraishi, T.
Auteure/Auteur
Sidana, A.
Auteure/Auteur
Shoji, S.
Auteure/Auteur
Stabile, A.
Auteure/Auteur
Valerio, M.
Auteure/Auteur
Tammisetti, V.S.
Auteure/Auteur
Phin Tan, W.
Auteure/Auteur
VAN DEN Bos, W.
Auteure/Auteur
Villers, A.
Auteure/Auteur
Willemse, P.P.
Auteure/Auteur
DE LA Rosette, J.
Auteure/Auteur
Polascik, T.
Auteure/Auteur
Sanchez-Salas, R.
Auteure/Auteur
Groupes de travail
Focal Therapy Society
Liens vers les personnes
Liens vers les unités
ISSN
2724-6442
Statut éditorial
Publié
Date de publication
2022-10
Volume
74
Numéro
5
Première page
581
Dernière page/numéro d’article
589
Peer-reviewed
Oui
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Publication Status: ppublish
Résumé
Focal therapy (FT) for prostate cancer (PCa) is promising. However, long-term oncological results are awaited and there is no consensus on follow-up strategies. Molecular biomarkers (MB) may be useful in selecting, treating and following up men undergoing FT, though there is limited evidence in this field to guide practice. We aimed to conduct a consensus meeting, endorsed by the Focal Therapy Society, amongst a large group of experts, to understand the potential utility of MB in FT for localized PCa.
A 38-item questionnaire was built following a literature search. The authors then performed three rounds of a Delphi Consensus using DelphiManager, using the GRADE grid scoring system, followed by a face-to-face expert meeting. Three areas of interest were identified and covered concerning MB for FT, 1) the current/present role; 2) the potential/future role; 3) the recommended features for future studies. Consensus was defined using a 70% agreement threshold.
Of 95 invited experts, 42 (44.2%) completed the three Delphi rounds. Twenty-four items reached a consensus and they were then approved at the meeting involving (N.=15) experts. Fourteen items reached a consensus on uncertainty, or they did not reach a consensus. They were re-discussed, resulting in a consensus (N.=3), a consensus on a partial agreement (N.=1), and a consensus on uncertainty (N.=10). A final list of statements were derived from the approved and discussed items, with the addition of three generated statements, to provide guidance regarding MB in the context of FT for localized PCa. Research efforts in this field should be considered a priority.
The present study detailed an initial consensus on the use of MB in FT for PCa. This is until evidence becomes available on the subject.
A 38-item questionnaire was built following a literature search. The authors then performed three rounds of a Delphi Consensus using DelphiManager, using the GRADE grid scoring system, followed by a face-to-face expert meeting. Three areas of interest were identified and covered concerning MB for FT, 1) the current/present role; 2) the potential/future role; 3) the recommended features for future studies. Consensus was defined using a 70% agreement threshold.
Of 95 invited experts, 42 (44.2%) completed the three Delphi rounds. Twenty-four items reached a consensus and they were then approved at the meeting involving (N.=15) experts. Fourteen items reached a consensus on uncertainty, or they did not reach a consensus. They were re-discussed, resulting in a consensus (N.=3), a consensus on a partial agreement (N.=1), and a consensus on uncertainty (N.=10). A final list of statements were derived from the approved and discussed items, with the addition of three generated statements, to provide guidance regarding MB in the context of FT for localized PCa. Research efforts in this field should be considered a priority.
The present study detailed an initial consensus on the use of MB in FT for PCa. This is until evidence becomes available on the subject.
PID Serval
serval:BIB_D3E83875F4A4
PMID
Date de création
2021-01-25T07:31:39.668Z
Date de création dans IRIS
2025-05-21T01:26:53Z