Titre
Alarm pheromone and kairomone detection via bitter taste receptors in the mouse Grueneberg ganglion.
Type
article
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Périodique
Auteur(s)
Moine, F.
Auteure/Auteur
Brechbühl, J.
Auteure/Auteur
Nenniger Tosato, M.
Auteure/Auteur
Beaumann, M.
Auteure/Auteur
Broillet, M.C.
Auteure/Auteur
Liens vers les personnes
Liens vers les unités
ISSN
1741-7007
Statut éditorial
Publié
Date de publication
2018-01-18
Volume
16
Numéro
1
Première page
12
Peer-reviewed
Oui
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: epublish
Publication Status: epublish
Résumé
The mouse Grueneberg ganglion (GG) is an olfactory subsystem specialized in the detection of volatile heterocyclic compounds signalling danger. The signalling pathways transducing the danger signals are only beginning to be characterized.
Screening chemical libraries for compounds structurally resembling the already-identified GG ligands, we found a new category of chemicals previously identified as bitter tastants that initiated fear-related behaviours in mice depending on their volatility and evoked neuronal responses in mouse GG neurons. Screening for the expression of signalling receptors of these compounds in the mouse GG yielded transcripts of the taste receptors Tas2r115, Tas2r131, Tas2r143 and their associated G protein α-gustducin (Gnat3). We were further able to confirm their expression at the protein level. Challenging these three G protein-coupled receptors in a heterologous system with the known GG ligands, we identified TAS2R143 as a chemical danger receptor transducing both alarm pheromone and predator-derived kairomone signals.
These results demonstrate that similar molecular elements might be used by the GG and by the taste system to detect chemical danger signals present in the environment.
Screening chemical libraries for compounds structurally resembling the already-identified GG ligands, we found a new category of chemicals previously identified as bitter tastants that initiated fear-related behaviours in mice depending on their volatility and evoked neuronal responses in mouse GG neurons. Screening for the expression of signalling receptors of these compounds in the mouse GG yielded transcripts of the taste receptors Tas2r115, Tas2r131, Tas2r143 and their associated G protein α-gustducin (Gnat3). We were further able to confirm their expression at the protein level. Challenging these three G protein-coupled receptors in a heterologous system with the known GG ligands, we identified TAS2R143 as a chemical danger receptor transducing both alarm pheromone and predator-derived kairomone signals.
These results demonstrate that similar molecular elements might be used by the GG and by the taste system to detect chemical danger signals present in the environment.
Sujets
PID Serval
serval:BIB_F64AEA348D4B
PMID
Open Access
Oui
Date de création
2018-01-27T12:11:17.811Z
Date de création dans IRIS
2025-05-21T05:12:36Z
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Nom
1-s2.0-S2211124717315991-main.pdf
Version du manuscrit
published
Taille
6.44 MB
Format
Adobe PDF
PID Serval
serval:BIB_F64AEA348D4B.P001
URN
urn:nbn:ch:serval-BIB_F64AEA348D4B0
Somme de contrôle
(MD5):7007d30f9e8aa2b5bcb6933577eebbc9