Titre
Protective effects of maternal nutritional supplementation with lactoferrin on growth and brain metabolism.
Type
article
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Périodique
Auteur(s)
Somm, E.
Auteure/Auteur
Larvaron, P.
Auteure/Auteur
van de Looij, Y.
Auteure/Auteur
Toulotte, A.
Auteure/Auteur
Chatagner, A.
Auteure/Auteur
Faure, M.
Auteure/Auteur
Métairon, S.
Auteure/Auteur
Mansourian, R.
Auteure/Auteur
Raymond, F.
Auteure/Auteur
Gruetter, R.
Auteure/Auteur
Wang, B.
Auteure/Auteur
Sizonenko, S.V.
Auteure/Auteur
Hüppi, P.S.
Auteure/Auteur
Liens vers les personnes
Liens vers les unités
ISSN
1530-0447
Statut éditorial
Publié
Date de publication
2014
Volume
75
Numéro
1-1
Première page
51
Dernière page/numéro d’article
61
Peer-reviewed
Oui
Langue
anglais
Notes
Publication types: Journal ArticlePublication Status: ppublish
Résumé
Background:Intrauterine growth restriction (IUGR) is a major risk factor for both perinatal and long-term morbidity. Bovine lactoferrin (bLf) is a major milk glycoprotein considered as a pleiotropic functional nutrient. The impact of maternal supplementation with bLf on IUGR-induced sequelae, including inadequate growth and altered cerebral development, remains unknown.Methods:IUGR was induced through maternal dexamethasone infusion (100 μg/kg during last gestational week) in rats. Maternal supplementation with bLf (0.85% in food pellet) was provided during both gestation and lactation. Pup growth was monitored, and Pup brain metabolism and gene expression were studied using in vivo (1)H NMR spectroscopy, quantitative PCR, and microarray in the hippocampus at postnatal day (PND)7.Results:Maternal bLf supplementation did not change gestational weight but increased the birth body weight of control pups (4%) with no effect on the IUGR pups. Maternal bLf supplementation allowed IUGR pups to recover a normalized weight at PND21 (weaning) improving catch-up growth. Significantly altered levels of brain metabolites (γ-aminobutyric acid, glutamate, N-acetylaspartate, and N-acetylaspartylglutamate) and transcripts (brain-derived neurotrophic factor (BDNF), divalent metal transporter 1 (DMT-1), and glutamate receptors) in IUGR pups were normalized with maternal bLf supplementation.Conclusion:Our data suggest that maternal bLf supplementation is a beneficial nutritional intervention able to revert some of the IUGR-induced sequelae, including brain hippocampal changes.
PID Serval
serval:BIB_C0F0003B100C
PMID
Open Access
Oui
Date de création
2014-02-11T08:56:06.076Z
Date de création dans IRIS
2025-05-20T23:50:48Z