Titre
Health care-associated native valve endocarditis: importance of non-nosocomial acquisition.
Type
article
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Périodique
Auteur(s)
Benito, N.
Auteure/Auteur
Miró, J.M.
Auteure/Auteur
de Lazzari, E.
Auteure/Auteur
Cabell, C.H.
Auteure/Auteur
del Río, A.
Auteure/Auteur
Altclas, J.
Auteure/Auteur
Commerford, P.
Auteure/Auteur
Delahaye, F.
Auteure/Auteur
Dragulescu, S.
Auteure/Auteur
Giamarellou, H.
Auteure/Auteur
Habib, G.
Auteure/Auteur
Kamarulzaman, A.
Auteure/Auteur
Kumar, A.S.
Auteure/Auteur
Nacinovich, F.M.
Auteure/Auteur
Suter, F.
Auteure/Auteur
Tribouilloy, C.
Auteure/Auteur
Venugopal, K.
Auteure/Auteur
Moreno, A.
Auteure/Auteur
Fowler, V.G.
Auteure/Auteur
Contributrices/contributeurs
Gordon, D.
Devi, U.
Spelman, D.
van der Meer JT.,
Kauffman, C.
Bradley, S.
Armstrong, W.
Giannitsioti, E.
Giamarellou, H.
Lerakis, S.
del Río, A.
Moreno, A.
Mestres, CA.
Pare, C.
de la Maria CG.,
de Lazzari, E.
Marco, F.
Gatell, JM.
Almela, M.
Azqueta, M.
Jiménez-Expósito£££Maria Jesús£££ MJ.,
Benito, N.
Sitges, M.
Claramonte, X.
Armero, Y.
Cervera, C.
Falces, C.
Heras, M.
Miro, JM.
Fernandez-Hidalgo, N.
de Vera PR.,
Tornos, P.
Falco, V.
Sidani, N.
Kanj-Sharara, S.
Kanafani, Z.
Raglio, A.
Goglio, A.
Gnecchi, F.
Suter, F.
Valsecchi, G.
Rizzi, M.
Ravasio, V.
Hoen, B.
Chirouze, C.
Giannitsiot, E.
Leroy, J.
Plesiat, P.
Bernard, Y.
Casey, A.
Lambert, P.
Watkin, R.
Elliott, T.
Baddley, J.
Patel, M.
Dismukes, W.
Caros, G.
Mathiron, AB.
Tribouilloy, C.
Goissen, T.
Delahaye, A.
Delahaye, F.
Vandenesch, F.
Vizzotti, C.
Nacinovich, FM.
Marin, M.
Trivi, M.
Lombardero, M.
Cortes, C.
Casabe, JH.
Altclas, J.
Kogan, S.
Clara, L.
Sanchez, M.
Commerford, A.
Hansa, C.
Deetlefs, E.
Ntsekhe, M.
Commerford, P.
Wray, D.
Steed, LL.
Church, P.
Cantey, R.
Morris, A.
Holland, D.
Murdoch, D.
Chambers, S.
Read, K.
Raymond, N.
Lang, S.
Kotsanas, D.
Korman, TM.
Peterson, G.
Southern PM.<Suffix>Jr</Suffix>,
Shah, M.
Bedimo, R.
Reddy, A.
Levine, D.
Dhar, G.
Hanlon-Feeney, A.
Hannan, M.
Kelly, S.
Wang, A.
Cabell, CH.
Woods, CW.
Sexton, DJ.
Corey, R.
Drew, L.
Lalani, T.
Fowler VG.<Suffix>Jr</Suffix>,
Chu, VH.
Mazaheri, B.
Neuerburg, C.
Naber, C.
Athan, E.
Henry, M.
Harris, O.
Alestig, E.
Olaison, L.
Wikstrom, L.
Snygg-Martin, U.
Francis, J.
Venugopal, K.
Nair, L.
Thomas, V.
Chaiworramukkun, J.
Pachirat, O.
Chetchotisakd, P.
Suwanich, T.
Kamarulzaman, A.
Tamin, SS.
Premru, MM.
Logar, M.
Lejko-Zupanc, T.
Orezzi, C.
Klein, J.
Bouza, E.
Moreno, M.
Rodríguez-Créixems, M.
Marín, M.
Fernández, M.
Muñoz, P.
Fernández£££Rocío£££ R.,
Ramallo, V.
Raoult, D.
Thuny, F.
Habib, G.
Casalta, JP.
Fournier, PE.
Chipigina, N.
Kirill, O.
Vinogradova, T.
Kulichenko, VP.
Butkevich, OM.
Lion, C.
Selton-Suty, C.
Alla, F.
Coyard, H.
Doco-Lecompte, T.
Durante-Mangoni, E.
Ragone, E.
Dialetto, G.
Tripodi, MF.
Utili, R.
Casillo, R.
Kumar, AS.
Sharma, G.
Dickerman, SA.
Street, A.
Eisen, DP.
McBryde, ES.
Grigg, L.
Abrutyn, E.
Michelet, C.
Tattevin, P.
Donnio, PY.
Fortes, CQ.
Edathodu, J.
Al-Hegelan, M.
Font, B.
Anguera, I.
Guma, JR.
Cereceda, M.
Oyonarte, MJ.
Mella, RM.
Garcia, P.
Jones, SB.
de Oliveira Ramos AI.,
Paiva, MG.
de Medeiros Tranchesi RA.,
Woon, LL.
Lum, LN.
Tan, RS.
Rees, D.
Kornecny, P.
Lawrence, R.
Dever, R.
Post, J.
Jones, P.
Ryan, S.
Harkness, J.
Feneley, M.
Rubinstein, E.
Strahilewitz, J.
Ionac, A.
Mornos, C.
Dragulescu, S.
Forno, D.
Cecchi, E.
De Rosa, F.
Imazio, M.
Trinchero, R.
Wiesbauer, F.
Gattringer, R.
Rubinstein, E.
Deans, G.
Andrasevic, AT.
Barsic, B.
Klinar, I.
Vincelj, J.
Bukovski, S.
Krajinovic, V.
Corey, GR.
Stafford, J.
Baloch, K.
Redick, T.
Harding, T.
Fowler VG.<Suffix>Jr</Suffix>,
Chu, VH.
Karchmer, AW.
Bayer, A.
Hoen, B.
Cabell, CH.
Sexton, DJ.
Durack, DT.
Rubinstein, E.
Corey, GR.
Miro, JM.
Olaison, L.
Moreillon, P.
Eykyn, S.
Fowler VG.<Suffix>Jr</Suffix>,
Chu, VH.
Wang, A.
Bayer, A.
Karchmer, AW.
Hoen, B.
Cabell, CH.
Murdoch, D.
Athan, E.
Corey, GR.
Miro, JM.
Fowler VG.<Suffix>Jr</Suffix>,
Chu, VH.
Groupes de travail
ICE-PCS (International Collaboration on Endocarditis Prospective Cohort Study) Investigators
Liens vers les personnes
Liens vers les unités
ISSN
1539-3704
Statut éditorial
Publié
Date de publication
2009
Volume
150
Numéro
9
Première page
586
Dernière page/numéro d’article
594
Langue
anglais
Notes
Publication types: Journal Article ; Multicenter Study ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Publication Status: ppublish
Résumé
BACKGROUND: The clinical profile and outcome of nosocomial and non-nosocomial health care-associated native valve endocarditis are not well defined.
OBJECTIVE: To compare the characteristics and outcomes of community-associated and nosocomial and non-nosocomial health care-associated native valve endocarditis.
DESIGN: Prospective cohort study.
SETTING: 61 hospitals in 28 countries.
PATIENTS: Patients with definite native valve endocarditis and no history of injection drug use who were enrolled in the ICE-PCS (International Collaboration on Endocarditis Prospective Cohort Study) from June 2000 to August 2005.
MEASUREMENTS: Clinical and echocardiographic findings, microbiology, complications, and mortality.
RESULTS: Health care-associated native valve endocarditis was present in 557 (34%) of 1622 patients (303 with nosocomial infection [54%] and 254 with non-nosocomial infection [46%]). Staphylococcus aureus was the most common cause of health care-associated infection (nosocomial, 47%; non-nosocomial, 42%; P = 0.30); a high proportion of patients had methicillin-resistant S. aureus (nosocomial, 57%; non-nosocomial, 41%; P = 0.014). Fewer patients with health care-associated native valve endocarditis had cardiac surgery (41% vs. 51% of community-associated cases; P < 0.001), but more of the former patients died (25% vs. 13%; P < 0.001). Multivariable analysis confirmed greater mortality associated with health care-associated native valve endocarditis (incidence risk ratio, 1.28 [95% CI, 1.02 to 1.59]).
LIMITATIONS: Patients were treated at hospitals with cardiac surgery programs. The results may not be generalizable to patients receiving care in other types of facilities or to those with prosthetic valves or past injection drug use.
CONCLUSION: More than one third of cases of native valve endocarditis in non-injection drug users involve contact with health care, and non-nosocomial infection is common, especially in the United States. Clinicians should recognize that outpatients with extensive out-of-hospital health care contacts who develop endocarditis have clinical characteristics and outcomes similar to those of patients with nosocomial infection.
PRIMARY FUNDING SOURCE: None.
OBJECTIVE: To compare the characteristics and outcomes of community-associated and nosocomial and non-nosocomial health care-associated native valve endocarditis.
DESIGN: Prospective cohort study.
SETTING: 61 hospitals in 28 countries.
PATIENTS: Patients with definite native valve endocarditis and no history of injection drug use who were enrolled in the ICE-PCS (International Collaboration on Endocarditis Prospective Cohort Study) from June 2000 to August 2005.
MEASUREMENTS: Clinical and echocardiographic findings, microbiology, complications, and mortality.
RESULTS: Health care-associated native valve endocarditis was present in 557 (34%) of 1622 patients (303 with nosocomial infection [54%] and 254 with non-nosocomial infection [46%]). Staphylococcus aureus was the most common cause of health care-associated infection (nosocomial, 47%; non-nosocomial, 42%; P = 0.30); a high proportion of patients had methicillin-resistant S. aureus (nosocomial, 57%; non-nosocomial, 41%; P = 0.014). Fewer patients with health care-associated native valve endocarditis had cardiac surgery (41% vs. 51% of community-associated cases; P < 0.001), but more of the former patients died (25% vs. 13%; P < 0.001). Multivariable analysis confirmed greater mortality associated with health care-associated native valve endocarditis (incidence risk ratio, 1.28 [95% CI, 1.02 to 1.59]).
LIMITATIONS: Patients were treated at hospitals with cardiac surgery programs. The results may not be generalizable to patients receiving care in other types of facilities or to those with prosthetic valves or past injection drug use.
CONCLUSION: More than one third of cases of native valve endocarditis in non-injection drug users involve contact with health care, and non-nosocomial infection is common, especially in the United States. Clinicians should recognize that outpatients with extensive out-of-hospital health care contacts who develop endocarditis have clinical characteristics and outcomes similar to those of patients with nosocomial infection.
PRIMARY FUNDING SOURCE: None.
PID Serval
serval:BIB_61A51B609E95
PMID
Date de création
2010-02-17T16:34:14.449Z
Date de création dans IRIS
2025-05-20T17:45:19Z