Titre
Functional and structural alterations in the cingulate motor area relate to decreased fronto-striatal coupling in major depressive disorder with psychomotor disturbances.
Type
article
Institution
Externe
Périodique
Auteur(s)
Liberg, B.
Auteure/Auteur
Klauser, P.
Auteure/Auteur
Harding, I.H.
Auteure/Auteur
Adler, M.
Auteure/Auteur
Rahm, C.
Auteure/Auteur
Lundberg, J.
Auteure/Auteur
Masterman, T.
Auteure/Auteur
Wachtler, C.
Auteure/Auteur
Jonsson, T.
Auteure/Auteur
Kristoffersen-Wiberg, M.
Auteure/Auteur
Pantelis, C.
Auteure/Auteur
Wahlund, B.
Auteure/Auteur
Liens vers les personnes
ISSN
1664-0640
Statut éditorial
Publié
Date de publication
2014
Volume
5
Première page
176
Peer-reviewed
Oui
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: epublish
Publication Status: epublish
Résumé
Psychomotor disturbances are a classic feature of major depressive disorders. These can manifest as lack of facial expressions and decreased speech production, reduced body posture and mobility, and slowed voluntary movement. The neural correlates of psychomotor disturbances in depression are poorly understood but it has been suggested that outputs from the cingulate motor area (CMA) to striatal motor regions, including the putamen, could be involved. We used functional and structural magnetic resonance imaging to conduct a region-of-interest analysis to test the hypotheses that neural activation patterns related to motor production and gray matter volumes in the CMA would be different between depressed subjects displaying psychomotor disturbances (n = 13) and matched healthy controls (n = 13). In addition, we conducted a psychophysiological interaction analysis to assess the functional coupling related to self-paced finger-tapping between the caudal CMA and the posterior putamen in patients compared to controls. We found a cluster of increased neural activation, adjacent to a cluster of decreased gray matter volume in the caudal CMA in patients compared to controls. The functional coupling between the left caudal CMA and the left putamen during finger-tapping task performance was additionally decreased in patients compared to controls. In addition, the strength of the functional coupling between the left caudal CMA and the left putamen was negatively correlated with the severity of psychomotor disturbances in the patient group. In conclusion, we found converging evidence for involvement of the caudal CMA and putamen in the generation of psychomotor disturbances in depression.
PID Serval
serval:BIB_46008E8E3D45
PMID
Open Access
Oui
Date de création
2019-02-07T08:30:14.926Z
Date de création dans IRIS
2025-05-20T15:34:55Z