Titre
Oral Dysbiosis and Inflammation in Parkinson's Disease
Type
article
Institution
Externe
Périodique
Auteur(s)
Fleury, V.
Auteure/Auteur
Zekeridou, A.
Auteure/Auteur
Lazarevic, V.
Auteure/Auteur
Gaia, N.
Auteure/Auteur
Giannopoulou, C.
Auteure/Auteur
Genton, L.
Auteure/Auteur
Cancela, J.
Auteure/Auteur
Girard, M.
Auteure/Auteur
Goldstein, R.
Auteure/Auteur
Bally, J. F.
Auteure/Auteur
Mombelli, A.
Auteure/Auteur
Schrenzel, J.
Auteure/Auteur
Burkhard, P. R.
Auteure/Auteur
Liens vers les personnes
ISSN
1877-718X
Statut éditorial
Publié
Date de publication
2021
Volume
11
Numéro
2
Première page
619
Dernière page/numéro d’article
631
Langue
anglais
Notes
Fleury, Vanessa
Zekeridou, Alkisti
Lazarevic, Vladimir
Gaia, Nadia
Giannopoulou, Catherine
Genton, Laurence
Cancela, Jose
Girard, Myriam
Goldstein, Rachel
Bally, Julien F
Mombelli, Andrea
Schrenzel, Jacques
Burkhard, Pierre R
eng
Netherlands
J Parkinsons Dis. 2021;11(2):619-631. doi: 10.3233/JPD-202459.
Zekeridou, Alkisti
Lazarevic, Vladimir
Gaia, Nadia
Giannopoulou, Catherine
Genton, Laurence
Cancela, Jose
Girard, Myriam
Goldstein, Rachel
Bally, Julien F
Mombelli, Andrea
Schrenzel, Jacques
Burkhard, Pierre R
eng
Netherlands
J Parkinsons Dis. 2021;11(2):619-631. doi: 10.3233/JPD-202459.
Résumé
BACKGROUND: Oral microbiota has largely escaped attention in Parkinson's disease (PD), despite its pivotal role in maintaining oral and systemic health. OBJECTIVE: The aim of our study was to examine the composition of the oral microbiota and the degree of oral inflammation in PD. METHODS: Twenty PD patients were compared to 20 healthy controls. Neurological, periodontal and dental examinations were performed as well as dental scaling and gingival crevicular fluid sampling for cytokines measurement (interleukine (IL)-1beta, IL-6, IL-1 receptor antagonist (RA), interferon-gamma and tumor necrosis factor (TNF)-alpha). Two months later, oral microbiota was sampled from saliva and subgingival dental plaque. A 16S rRNA gene amplicon sequencing was used to assess bacterial communities. RESULTS: PD patients were in the early and mid-stage phases of their disease (Hoehn & Yahr 2-2.5). Dental and periodontal parameters did not differ between groups. The levels of IL-1beta and IL-1RA were significantly increased in patients compared to controls with a trend for an increased level of TNF-alpha in patients. Both saliva and subgingival dental plaque microbiota differed between patients and controls. Streptococcus mutans, Kingella oralis, Actinomyces AFQC_s, Veillonella AFUJ_s, Scardovia, Lactobacillaceae, Negativicutes and Firmicutes were more abundant in patients, whereas Treponema KE332528_s, Lachnospiraceae AM420052_s, and phylum SR1 were less abundant. CONCLUSION: Our findings show that the oral microbiome is altered in early and mid-stage PD. Although PD patients had good dental and periodontal status, local inflammation was already present in the oral cavity. The relationship between oral dysbiosis, inflammation and the pathogenesis of PD requires further study.
PID Serval
serval:BIB_61D996FCA1E9
PMID
Date de création
2021-05-21T08:09:44.174Z
Date de création dans IRIS
2025-05-21T01:25:34Z