Titre
Interplay of vitamin D, erythropoiesis, and the renin-angiotensin system.
Type
synthèse (review)
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Périodique
Auteur(s)
Santoro, D.
Auteure/Auteur
Caccamo, D.
Auteure/Auteur
Lucisano, S.
Auteure/Auteur
Buemi, M.
Auteure/Auteur
Sebekova, K.
Auteure/Auteur
Teta, D.
Auteure/Auteur
De Nicola, L.
Auteure/Auteur
Liens vers les personnes
Liens vers les unités
ISSN
2314-6141
Statut éditorial
Publié
Date de publication
2015
Volume
2015
Première page
145828
Langue
anglais
Résumé
For many years deficiency of vitamin D was merely identified and assimilated to the presence of bone rickets. It is now clear that suboptimal vitamin D status may be correlated with several disorders and that the expression of 1-α-hydroxylase in tissues other than the kidney is widespread and of clinical relevance. Recently, evidence has been collected to suggest that, beyond the traditional involvement in mineral metabolism, vitamin D may interact with other kidney hormones such as renin and erythropoietin. This interaction would be responsible for some of the systemic and renal effects evoked for the therapy with vitamin D. The administration of analogues of vitamin D has been associated with an improvement of anaemia and reduction in ESA requirements. Moreover, vitamin D deficiency could contribute to an inappropriately activated or unsuppressed RAS, as a mechanism for progression of CKD and/or cardiovascular disease. Experimental data on the anti-RAS and anti-inflammatory effects treatment with active vitamin D analogues suggest a therapeutic option particularly in proteinuric CKD patients. This option should be considered for those subjects that are intolerant to anti-RAS agents or, as add-on therapy, in those already treated with anti-RAS but not reaching the safe threshold level of proteinuria.
PID Serval
serval:BIB_A4C535FEA3C1
PMID
Open Access
Oui
Date de création
2015-07-23T07:45:37.812Z
Date de création dans IRIS
2025-05-21T03:49:25Z
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Nom
26000281_BIB_A4C535FEA3C1.pdf
Version du manuscrit
published
Taille
621.53 KB
Format
Adobe PDF
PID Serval
serval:BIB_A4C535FEA3C1.P001
URN
urn:nbn:ch:serval-BIB_A4C535FEA3C10
Somme de contrôle
(MD5):a20823159a116280286ea9b260e9cdf2