Titre
Enantiospecific pharmacokinetics of intravenous dexmedetomidine in beagles.
Type
article
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Auteur(s)
Levionnois, O.L.
Auteure/Auteur
Barbarossa, A.
Auteure/Auteur
Bardhi, A.
Auteure/Auteur
Siegenthaler, J.
Auteure/Auteur
Forss Pleyers, T.
Auteure/Auteur
Guidi, M.
Auteure/Auteur
Spadavecchia, C.
Auteure/Auteur
Raillard, M.
Auteure/Auteur
Liens vers les personnes
Liens vers les unités
ISSN
1365-2885
Statut éditorial
Publié
Date de publication
2022-07
Volume
45
Numéro
4
Première page
366
Dernière page/numéro d’article
372
Peer-reviewed
Oui
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Publication Status: ppublish
Résumé
The goal of this study was to investigate the pharmacokinetic (PK) behaviour of dexmedetomidine in dogs administered as a pure enantiomer versus as part of a racemic mixture. Eight unmedicated intact purpose-bread beagles were included. Two intravenous treatments of either medetomidine or dexmedetomidine were administered at 10- to 14-day intervals. Atipamezole or saline solution was administered intramuscularly 45 min later. Venous blood samples were collected into EDTA collection tubes, and the quantification of dexmedetomidine and levomedetomidine was performed by chiral LC-MS/MS. All dogs appeared sedated after each treatment without complication. Plasma concentrations of levomedetomidine were measured only in the racemic group and were 51.4% (51.4%-56.1%) lower than dexmedetomidine. Non-compartmental analysis (NCA) was performed for both drugs, while dexmedetomidine data were further described using a population pharmacokinetic approach. A standard two-compartment mammillary model with linear elimination with combined additive and multiplicative error model for residual unexplained variability was established for dexmedetomidine. An exponential model was finally retained to describe inter-individual variability on parameters of clearance (Cl <sub>1</sub> ) and central and peripheral volumes of distribution (V <sub>1</sub> , V <sub>2</sub> ). No effect of occurrence, levomedetomidine or atipamezole could be observed on dexmedetomidine PK parameters. Dexmedetomidine did not undergo significantly different PK when administered alone or as part of the racemic mixture in otherwise unmedicated dogs.
PID Serval
serval:BIB_F2C44CF39F4A
PMID
Open Access
Oui
Date de création
2022-05-13T16:18:20.094Z
Date de création dans IRIS
2025-05-21T05:15:26Z
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Nom
35484944_BIB_F2C44CF39F4A.pdf
Version du manuscrit
published
Licence
https://creativecommons.org/licenses/by-nc/4.0
Taille
1.2 MB
Format
Adobe PDF
PID Serval
serval:BIB_F2C44CF39F4A.P001
URN
urn:nbn:ch:serval-BIB_F2C44CF39F4A8
Somme de contrôle
(MD5):1227de429f63969268adf34687fc15be