Titre
M2-like, dermal macrophages are maintained via IL-4/CCL24-mediated cooperative interaction with eosinophils in cutaneous leishmaniasis.
Type
article
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Périodique
Auteur(s)
Lee, S.H.
Auteure/Auteur
Chaves, M.M.
Auteure/Auteur
Kamenyeva, O.
Auteure/Auteur
Gazzinelli-Guimaraes, P.H.
Auteure/Auteur
Kang, B.
Auteure/Auteur
Pessenda, G.
Auteure/Auteur
Passelli, K.
Auteure/Auteur
Tacchini-Cottier, F.
Auteure/Auteur
Kabat, J.
Auteure/Auteur
Jacobsen, E.A.
Auteure/Auteur
Nutman, T.B.
Auteure/Auteur
Sacks, D.L.
Auteure/Auteur
Liens vers les personnes
Liens vers les unités
ISSN
2470-9468
Statut éditorial
Publié
Date de publication
2020-04-10
Volume
5
Numéro
46
Première page
eaaz4415
Peer-reviewed
Oui
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Publication Status: ppublish
Résumé
Tissue-resident macrophages (TRMs) maintain tissue homeostasis, but they can also provide a replicative niche for intracellular pathogens such as Leishmania How dermal TRMs proliferate and maintain their M2 properties even in the strong T <sub>H</sub> 1 environment of the L. major infected dermis is not clear. Here, we show that, in infected mice lacking IL-4/13 from eosinophils, dermal TRMs shifted to a proinflammatory state, their numbers declined, and disease was attenuated. Intravital microscopy revealed a rapid infiltration of eosinophils followed by their tight interaction with dermal TRMs. IL-4-stimulated dermal TRMs, in concert with IL-10, produced a large amount of CCL24, which functioned to amplify eosinophil influx and their interaction with dermal TRMs. An intraperitoneal helminth infection model also demonstrated a requirement for eosinophil-derived IL-4 to maintain tissue macrophages through a CCL24-mediated amplification loop. CCL24 secretion was confined to resident macrophages in other tissues, implicating eosinophil-TRM cooperative interactions in diverse inflammatory settings.
PID Serval
serval:BIB_493458DC46CB
PMID
Date de création
2020-04-25T19:28:48.586Z
Date de création dans IRIS
2025-05-20T17:03:05Z