Titre
Polymorphisms and haplotypes in TLR9 and MYD88 are associated with the development of Hodgkin's lymphoma: a candidate-gene association study.
Type
article
Institution
Externe
Périodique
Auteur(s)
Mollaki, V.
Auteure/Auteur
Georgiadis, T.
Auteure/Auteur
Tassidou, A.
Auteure/Auteur
Ioannou, M.
Auteure/Auteur
Daniil, Z.
Auteure/Auteur
Koutsokera, A.
Auteure/Auteur
Papathanassiou, A.A.
Auteure/Auteur
Zintzaras, E.
Auteure/Auteur
Vassilopoulos, G.
Auteure/Auteur
Liens vers les personnes
ISSN
1435-232X
Statut éditorial
Publié
Date de publication
2009-11
Volume
54
Numéro
11
Première page
655
Dernière page/numéro d’article
659
Peer-reviewed
Oui
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Publication Status: ppublish
Résumé
Toll-like receptors (TLRs) and myeloid differentiation primary response protein 88 (MYD88) gene polymorphisms may be involved in the pathogenesis of Hodgkin's lymphoma (HL) through altered immunoregulatory and inflammatory responses. A candidate-gene association study was conducted to investigate the association between TLR9 -1237T>C, TLR9 2848A>G, MYD88 -938C>A and MYD88 1944C>G gene polymorphisms and the risk for HL. The impact of haplotypes was also examined. The study showed that carriership for -1237C and 2848A was associated with an increased risk for HL (odds ratio (OR)=2.53 (1.36-4.71) and OR=6.20 (1.3-28.8)). The MYD88 polymorphisms produced nonsignificant results. The estimated frequencies of the TLR9/1237C-2848A and MYD88/938C-1944G haplotypes were also significantly different between HL and controls (P<0.01). In addition, a significant difference between HL and controls was observed for the TLR9/1237C-TLR9/2848A-MYD88/938C-MYD88/1944C haplotypes (P<0.01). In conclusion, our study showed that TLR polymorphisms, and TLR9 and MYD88 haplotypes are related to the development of HL.
PID Serval
serval:BIB_D5DD8D66EA43
PMID
Open Access
Oui
Date de création
2019-07-19T17:41:40.747Z
Date de création dans IRIS
2025-05-21T04:32:51Z