Titre
Evolutionary and ecological role of extracellular contractile injection systems: from threat to weapon.
Type
synthèse (review)
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Périodique
Auteur(s)
Heiman, C.M.
Auteure/Auteur
Vacheron, J.
Co-dernière auteure/Co-dernier auteur
Keel, C.
Co-dernière auteure/Co-dernier auteur
Liens vers les personnes
Liens vers les unités
ISSN
1664-302X
Statut éditorial
Publié
Date de publication
2023
Volume
14
Première page
1264877
Peer-reviewed
Oui
Langue
anglais
Notes
Publication types: Journal Article ; Review
Publication Status: epublish
Publication Status: epublish
Résumé
Contractile injection systems (CISs) are phage tail-related structures that are encoded in many bacterial genomes. These devices encompass the cell-based type VI secretion systems (T6SSs) as well as extracellular CISs (eCISs). The eCISs comprise the R-tailocins produced by various bacterial species as well as related phage tail-like structures such as the antifeeding prophages (Afps) of Serratia entomophila, the Photorhabdus virulence cassettes (PVCs), and the metamorphosis-associated contractile structures (MACs) of Pseudoalteromonas luteoviolacea. These contractile structures are released into the extracellular environment upon suicidal lysis of the producer cell and play important roles in bacterial ecology and evolution. In this review, we specifically portray the eCISs with a focus on the R-tailocins, sketch the history of their discovery and provide insights into their evolution within the bacterial host, their structures and how they are assembled and released. We then highlight ecological and evolutionary roles of eCISs and conceptualize how they can influence and shape bacterial communities. Finally, we point to their potential for biotechnological applications in medicine and agriculture.
PID Serval
serval:BIB_CD75D9947DAA
PMID
Open Access
Oui
Date de création
2023-10-13T06:40:14.886Z
Date de création dans IRIS
2025-05-21T02:57:30Z
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Nom
Heiman-FronMicrobiol-2023 eCIS review.pdf
Version du manuscrit
published
Licence
https://creativecommons.org/licenses/by/4.0
Taille
2.78 MB
Format
Adobe PDF
PID Serval
serval:BIB_CD75D9947DAA.P002
URN
urn:nbn:ch:serval-BIB_CD75D9947DAA4
Somme de contrôle
(MD5):cabeaced7a3e0d51411943c13ddf0125