Titre
Platelet-derived growth factor and its receptor in lungs from patients with asthma and chronic airflow obstruction.
Type
article
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Périodique
Auteur(s)
Aubert, J.D.
Auteure/Auteur
Hayashi, S.
Auteure/Auteur
Hards, J.
Auteure/Auteur
Bai, T.R.
Auteure/Auteur
Paré, P.D.
Auteure/Auteur
Hogg, J.C.
Auteure/Auteur
Liens vers les personnes
Liens vers les unités
ISSN
0002-9513
Statut éditorial
Publié
Date de publication
1994
Volume
266
Numéro
6 Pt 1
Première page
L655
Dernière page/numéro d’article
L663
Langue
anglais
Résumé
The airway walls of patients who have asthma or chronic obstructive pulmonary disease (COPD) are thickened by an increase in the amount of smooth muscle and connective tissue. Platelet-derived growth factor (PDGF) is a candidate cytokine for this increase because it can produce smooth muscle proliferation in vitro. The present study was designed to examine the expression of PDGF and its receptor (PDGFR) in lungs from six asthmatics, six patients with COPD, and six patients with normal lung function. PDGF was immunolocalized to tissue macrophages, but the number of PDGF-positive cells was similar in all three groups. PDGFR-beta was rarely expressed on interstitial cells, and, occasionally, on bronchial epithelium. Northern blotting, performed on tissue from the same groups, showed a positive correlation of PDGF(B) with PDGFR-beta mRNA level (r = 0.74, P < 0.001) and a higher abundance of PDGF(B) and PDGFR-beta mRNA in the asthmatics vs. the COPD (P < 0.05). We conclude that PDGF and its receptor are expressed in human lungs but do not correlate closely with the structural changes in diseased airways.
PID Serval
serval:BIB_6B33E2C0A553
PMID
Date de création
2008-01-21T11:54:15.435Z
Date de création dans IRIS
2025-05-20T15:19:49Z