Titre
Exploring the Expression of the «Dark Matter» of the Genome in Mesothelioma for Potentially Predictive Biomarkers for Prognosis and Immunotherapy.
Type
article
Institution
Externe
Périodique
Auteur(s)
Felley-Bosco, E.
Auteure/Auteur
Liens vers les personnes
ISSN
2072-6694
Statut éditorial
Publié
Date de publication
2023-05-29
Volume
15
Numéro
11
Peer-reviewed
Oui
Langue
anglais
Notes
Publication types: Journal Article ; Review
Publication Status: epublish
Publication Status: epublish
Résumé
Recent high-throughput RNA sequencing technologies have confirmed that a large part of the non-coding genome is transcribed. The priority for further investigations is nevertheless generally given in cancer to coding sequences, due to the obvious interest of finding therapeutic targets. In addition, several RNA-sequencing pipelines eliminate repetitive sequences, which are difficult to analyze. In this review, we shall focus on endogenous retroviruses. These sequences are remnants of ancestral germline infections by exogenous retroviruses. These sequences represent 8% of human genome, meaning four-fold the fraction of the genome encoding for proteins. These sequences are generally mostly repressed in normal adult tissues, but pathological conditions lead to their de-repression. Specific mesothelioma-associated endogenous retrovirus expression and their association to clinical outcome is discussed.
PID Serval
serval:BIB_DF891DB3E0EE
PMID
Open Access
Oui
Date de création
2023-06-12T13:36:08.406Z
Date de création dans IRIS
2025-05-21T00:55:13Z