Titre
IncP-1 R plasmids decrease the serum resistance and the virulence of Pseudomonas aeruginosa.
Type
article
Institution
Externe
Périodique
Journal of General Microbiology
Auteur(s)
Wretlind, B.
Auteure/Auteur
Becker, K.
Auteure/Auteur
Haas, D.
Auteure/Auteur
Liens vers les personnes
ISSN
0022-1287
Statut éditorial
Publié
Date de publication
1985
Volume
131
Numéro
10
Première page
2701
Dernière page/numéro d’article
2704
Langue
anglais
Résumé
Pseudomonas aeruginosa strain PAO1 was compared to PAO1 strains containing an IncP-1 R plasmid (RP1, R68, or R68.45) in an experimental mouse burn infection model. All R plasmids tested caused a 10- to 400-fold increase in mean lethal dose (LD50). The decrease in virulence produced by plasmids R68 and R68.45 was significantly greater than the decrease caused by the closely related plasmid RP1. All plasmids also led to an increased sensitivity of strain PAO1 to human serum bactericidal activity. Virulence and serum resistance of strain PAO1 were restored by curing of the entire plasmid R68.45 but not by deletions in the plasmid's transfer gene regions.
PID Serval
serval:BIB_5F038DECA145
PMID
Date de création
2008-01-25T16:01:32.166Z
Date de création dans IRIS
2025-05-20T13:47:24Z