Titre
Selected contribution: long-term effects of beta(2)-adrenergic receptor stimulation on alveolar fluid clearance in mice.
Type
article
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Périodique
Auteur(s)
Sartori, C.
Auteure/Auteur
Fang, X.
Auteure/Auteur
McGraw, D.W.
Auteure/Auteur
Koch, P.
Auteure/Auteur
Snider, M.E.
Auteure/Auteur
Folkesson, H.G.
Auteure/Auteur
Matthay, M.A.
Auteure/Auteur
Liens vers les personnes
Liens vers les unités
ISSN
8750-7587
Statut éditorial
Publié
Date de publication
2002
Volume
93
Numéro
5
Première page
1875
Dernière page/numéro d’article
1880
Peer-reviewed
Oui
Langue
anglais
Notes
Publication types: Journal Article
Résumé
Stimulation of active fluid transport with beta-adrenergic receptor (betaAR) agonists can accelerate the resolution of alveolar edema. However, chronic betaAR-agonist administration may cause betaAR desensitization and downregulation that may impair physiological responsiveness to betaAR-agonist stimulation. Therefore, we measured baseline and terbutaline- (10(-3) M) stimulated alveolar fluid clearance in mice that received subcutaneously (miniosmotic pumps) either saline or albuterol (2 mg. kg(-1). day(-1)) for 1, 3, or 6 days. Continuous albuterol administration increased plasma albuterol levels (10(-5) M), an effect that was associated with 1) a significant decrease in betaAR density and 2) attenuation, but not ablation, of maximal terbutaline-induced cAMP production. Forskolin-mediated cAMP-release was unaffected. Continuous albuterol infusion stimulated alveolar fluid clearance on day 1 but did not increase alveolar fluid clearance on days 3 and 6. However, terbutaline-stimulated alveolar fluid clearance in albuterol-treated mice was not reduced compared with saline-treated mice. Despite significant reductions in betaAR density and agonist-mediated cAMP production by long-term betaAR-agonist exposure, maximal betaAR-agonist-mediated increase in alveolar fluid clearance is not diminished in mice.
Sujets
PID Serval
serval:BIB_0654D698B00D
PMID
Date de création
2008-02-22T14:02:40.391Z
Date de création dans IRIS
2025-05-20T17:09:21Z