Titre
Role of Chlamydia trachomatis in miscarriage.
Type
article
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Périodique
Auteur(s)
Baud, D.
Auteure/Auteur
Goy, G.
Auteure/Auteur
Jaton, K.
Auteure/Auteur
Osterheld, M.C.
Auteure/Auteur
Blumer, S.
Auteure/Auteur
Borel, N.
Auteure/Auteur
Vial, Y.
Auteure/Auteur
Hohlfeld, P.
Auteure/Auteur
Pospischil, A.
Auteure/Auteur
Greub, G.
Auteure/Auteur
Liens vers les personnes
ISSN
1080-6059
Statut éditorial
Publié
Date de publication
2011
Volume
17
Numéro
9
Première page
1630
Dernière page/numéro d’article
1635
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Publication Status: ppublish
Résumé
To determine the role of Chlamydia trachomatis in miscarriage, we prospectively collected serum, cervicovaginal swab specimens, and placental samples from 386 women with and without miscarriage. Prevalence of immunoglobulin G against C. trachomatis was higher in the miscarriage group than in the control group (15.2% vs. 7.3%; p = 0.018). Association between C. trachomatis-positive serologic results and miscarriage remained significant after adjustment for age, origin, education, and number of sex partners (odds ratio 2.3, 95% confidence interval 1.1-4.9). C. trachomatis DNA was more frequently amplified from products of conception or placenta from women who had a miscarriage (4%) than from controls (0.7%; p = 0.026). Immunohistochemical analysis confirmed C. trachomatis in placenta from 5 of 7 patients with positive PCR results, whereas results of immunohistochemical analysis were negative in placenta samples from all 8 negative controls tested. Associations between miscarriage and serologic/molecular evidence of C. trachomatis infection support its role in miscarriage.
PID Serval
serval:BIB_70C5A8B1F2B8
PMID
Open Access
Oui
Date de création
2011-09-29T07:50:06.149Z
Date de création dans IRIS
2025-05-21T00:27:55Z
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Nom
BIB_70C5A8B1F2B8.P001.pdf
Version du manuscrit
preprint
Taille
220.3 KB
Format
Adobe PDF
PID Serval
serval:BIB_70C5A8B1F2B8.P001
URN
urn:nbn:ch:serval-BIB_70C5A8B1F2B80
Somme de contrôle
(MD5):e838b423d1aa02703c025d9d09281881