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  4. Exploring the potential carcinogenic role of arsenic in gallbladder cancer.
 
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Titre

Exploring the potential carcinogenic role of arsenic in gallbladder cancer.

Type
article
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Périodique
European Journal of Cancer Prevention  
Auteur(s)
Ganesan, N.
Auteure/Auteur
Bambino, K.
Auteure/Auteur
Boffetta, P.
Auteure/Auteur
Labgaa, I.
Auteure/Auteur
Liens vers les personnes
Labgaa, Ismail  
Liens vers les unités
Chirurgie viscérale  
ISSN
1473-5709
Statut éditorial
Publié
Date de publication
2020-03
Volume
29
Numéro
2
Première page
100
Dernière page/numéro d’article
109
Peer-reviewed
Oui
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Résumé
Gallbladder cancer (GBC) is an aggressive malignancy, associated with dismal outcomes. Although several risk factors including age, sex, and gallstones have been postulated, epidemiologic determinants of the disease remain largely uncovered. Moreover, the implication of environmental toxicants as possible risk factors is increasingly suspected. Arsenic (As), an established human carcinogen, is a natural contaminant of groundwater and has a geographic distribution similar to GBC incidence. This, combined with As metabolites being partially excreted in bile, raised the hypothesis that As may represent a carcinogenic hazard for the gallbladder. We conducted an analysis of the association between As concentration in groundwater and incidence rates of GBC worldwide in 52 countries. The USA, India, and Taiwan were selected on the basis of availability and quality of data for further investigation at a county-level. Relationships between As levels and GBC incidence were assessed using multivariable linear regression analyses. Analyses revealed significant associations between high As concentrations in groundwater and increased GBC incidences. Among women, correlations were observed worldwide (Spearman = 0.31, P = 0.028), in Taiwan (Spearman = 0.57, P = 0.005) and in India (R = 0.23, P = 0.006). In men, a correlation was observed in India (R = 0.26, P = 0.009) and a modest correlation was identified in the USA (Spearman = 0.14, P = 0.026). These results provide some support to the hypothesis of an association between high exposures to As-contaminated water on GBC, which appeared more prominent in women. Further observational and molecular studies, conducted at the individual level, are required to confirm this association and decipher its nature.
PID Serval
serval:BIB_EB6A314DBE94
DOI
10.1097/CEJ.0000000000000521
PMID
31145133
Permalien
https://iris.unil.ch/handle/iris/205852
Date de création
2019-06-18T15:36:48.112Z
Date de création dans IRIS
2025-05-21T03:04:02Z
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