Titre
Analysis of bisphenols in soft drinks by on-line solid phase extraction fast liquid chromatography-tandem mass spectrometry.
Type
article
Institution
Externe
Périodique
Auteur(s)
Gallart-Ayala, H.
Auteure/Auteur
Moyano, E.
Auteure/Auteur
Galceran, M.T.
Auteure/Auteur
Liens vers les personnes
ISSN
1873-4324
Statut éditorial
Publié
Date de publication
2011-01-10
Volume
683
Numéro
2
Première page
227
Dernière page/numéro d’article
233
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Publication Status: ppublish
Résumé
In this study, an automated on-line solid-phase extraction coupled to fast liquid chromatography-tandem mass spectrometry (on-line SPE fast LC-MS/MS) method was developed for the simultaneous analysis of bisphenol A (BPA), bisphenol F (BPF), bisphenol E (BPE), bisphenol B (BPB) and bisphenol S (BPS) in canned soft drinks without any previous sample treatment. A C18 (12 μm particle size) loading column was used for the SPE on-line preconcentration before the liquid chromatography baseline separation of bisphenol compounds using a C18 Fused-Core™ (50 mm × 2.1 mm i.d.) column, which took less than 3 min. Gradient elution and heated electrospray were used to reduce matrix effect and improve ionization efficiency. To select the most intense and selective transitions, fragmentation studies were performed by multiple-stage mass spectrometry in an ion trap mass analyzer and tandem mass spectrometry in a triple quadrupole instrument, this latter instrument being used for quantitation in SRM mode. Quality parameters of the method were established and we obtained a simple, fast, reproducible (RSD values lower than 10%) and accurate (precision higher than 93%) method for the analysis of bisphenols in canned soft drinks at the ng L(-1) level using matrix-matched calibration.
PID Serval
serval:BIB_23B97E7AB372
PMID
Date de création
2017-06-02T12:33:54.843Z
Date de création dans IRIS
2025-05-20T14:53:10Z