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  4. Naturally acquired MAGE-A10- and SSX-2-specific CD8+ T cell responses in patients with hepatocellular carcinoma.
 
  • DĆ©tails
Titre

Naturally acquired MAGE-A10- and SSX-2-specific CD8+ T cell responses in patients with hepatocellular carcinoma.

Type
article
Institution
UNIL/CHUV/UnisantƩ + institutions partenaires
PƩriodique
The Journal of Immunology  
Auteur(s)
Bricard, G.
Auteure/Auteur
Bouzourene, H.
Auteure/Auteur
Martinet, O.
Auteure/Auteur
Rimoldi, D.
Auteure/Auteur
Halkic, N.
Auteure/Auteur
Gillet, M.
Auteure/Auteur
Chaubert, P.
Auteure/Auteur
Macdonald, H.R.
Auteure/Auteur
Romero, P.
Auteure/Auteur
Cerottini, J.C.
Auteure/Auteur
Speiser, D.E.
Auteure/Auteur
Liens vers les personnes
Cerottini, Jean-Charles  
Romero, Pedro  
Speiser, Daniel  
Halkic, Nermin  
Bouzourene, Hanifa  
Macdonald, Hugh Robson  
Rimoldi Huggett, Donata  
Liens vers les unitƩs
Ludwig Institute for Cancer Research  
Direction DC  
Institut universitaire de pathologie (IUPA)  
ISSN
0022-1767
Statut Ʃditorial
PubliƩ
Date de publication
2005
Volume
174
NumƩro
3
PremiĆØre page
1709
DerniĆØre page/numĆ©ro d’article
1716
Peer-reviewed
Oui
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
RƩsumƩ
Immunotherapy is being proposed to treat patients with hepatocellular carcinoma (HCC). However, more detailed knowledge on tumor Ag expression and specific immune cells is required for the preparation of highly targeted vaccines. HCC express a variety of tumor-specific Ags, raising the question whether CTL specific for such Ags exist in HCC patients. Indeed, a recent study revealed CTLs specific for two cancer-testis (CT) Ags (MAGE-A1 and MAGE-A3) in tumor infiltrating lymphocytes of HCC patients. Here we assessed the presence of T cells specific for additional CT Ags: MAGE-A10, SSX-2, NY-ESO-1, and LAGE-1, which are naturally immunogenic as demonstrated in HLA-A2(+) melanoma patients. In two of six HLA-A2(+) HCC patients, we found that MAGE-A10- and/or SSX-2-specific CD8(+) T cells naturally responded to the disease, because they were enriched in tumor lesions but not in nontumoral liver. Isolated T cells specifically and strongly killed tumor cells in vitro, providing evidence that these CTL were selected in vivo for high avidity Ag recognition. Therefore, besides melanoma, HCC is the second solid human tumor with clear evidence for in vivo tumor recognition by T cells, providing the rational for specific immunotherapy, based on immunization with CT Ags such as MAGE-A10 and SSX-2.
Sujets

Aged

Aged, 80 and over

Antigen Presentation

Antigens, Neoplasm/bi...

Antigens, Neoplasm/im...

Antigens, Surface

CD8-Positive T-Lympho...

CD8-Positive T-Lympho...

Carcinoma, Hepatocell...

Carcinoma, Hepatocell...

Cell Line, Tumor

Cytotoxicity Tests, I...

Epitopes, T-Lymphocyt...

Female

HLA-A2 Antigen/biosyn...

Humans

Immunity, Innate

Leukocytes, Mononucle...

Leukocytes, Mononucle...

Liver Neoplasms/immun...

Liver Neoplasms/patho...

Lymphocytes, Tumor-In...

Lymphocytes, Tumor-In...

Male

Melanoma/immunology

Membrane Proteins/bio...

Membrane Proteins/imm...

Neoplasm Proteins/bio...

Neoplasm Proteins/imm...

Repressor Proteins/bi...

Repressor Proteins/im...

PID Serval
serval:BIB_1874344F750A
PMID
15661935
WOS
000226571300071
Permalien
https://iris.unil.ch/handle/iris/70143
Open Access
Oui
Date de crƩation
2008-01-28T10:14:13.330Z
Date de crƩation dans IRIS
2025-05-20T16:14:26Z
Fichier(s)
En cours de chargement...
Vignette d'image
Nom

Naturally_Acquired_MAGE-A10-_and_SSX-2-Specific_CD.pdf

Version du manuscrit

published

Taille

616.31 KB

Format

Adobe PDF

PID Serval

serval:BIB_1874344F750A.P001

URN

urn:nbn:ch:serval-BIB_1874344F750A2

Somme de contrƓle

(MD5):be43f36d088b4f777ff8fbd5fcd5d23b

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