Titre
Naturally acquired MAGE-A10- and SSX-2-specific CD8+ T cell responses in patients with hepatocellular carcinoma.
Type
article
Institution
UNIL/CHUV/UnisantƩ + institutions partenaires
PƩriodique
Auteur(s)
Bricard, G.
Auteure/Auteur
Bouzourene, H.
Auteure/Auteur
Martinet, O.
Auteure/Auteur
Rimoldi, D.
Auteure/Auteur
Halkic, N.
Auteure/Auteur
Gillet, M.
Auteure/Auteur
Chaubert, P.
Auteure/Auteur
Macdonald, H.R.
Auteure/Auteur
Romero, P.
Auteure/Auteur
Cerottini, J.C.
Auteure/Auteur
Speiser, D.E.
Auteure/Auteur
Liens vers les unitƩs
ISSN
0022-1767
Statut Ʃditorial
PubliƩ
Date de publication
2005
Volume
174
NumƩro
3
PremiĆØre page
1709
DerniĆØre page/numĆ©ro dāarticle
1716
Peer-reviewed
Oui
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Publication Status: ppublish
RƩsumƩ
Immunotherapy is being proposed to treat patients with hepatocellular carcinoma (HCC). However, more detailed knowledge on tumor Ag expression and specific immune cells is required for the preparation of highly targeted vaccines. HCC express a variety of tumor-specific Ags, raising the question whether CTL specific for such Ags exist in HCC patients. Indeed, a recent study revealed CTLs specific for two cancer-testis (CT) Ags (MAGE-A1 and MAGE-A3) in tumor infiltrating lymphocytes of HCC patients. Here we assessed the presence of T cells specific for additional CT Ags: MAGE-A10, SSX-2, NY-ESO-1, and LAGE-1, which are naturally immunogenic as demonstrated in HLA-A2(+) melanoma patients. In two of six HLA-A2(+) HCC patients, we found that MAGE-A10- and/or SSX-2-specific CD8(+) T cells naturally responded to the disease, because they were enriched in tumor lesions but not in nontumoral liver. Isolated T cells specifically and strongly killed tumor cells in vitro, providing evidence that these CTL were selected in vivo for high avidity Ag recognition. Therefore, besides melanoma, HCC is the second solid human tumor with clear evidence for in vivo tumor recognition by T cells, providing the rational for specific immunotherapy, based on immunization with CT Ags such as MAGE-A10 and SSX-2.
Sujets
PID Serval
serval:BIB_1874344F750A
PMID
Open Access
Oui
Date de crƩation
2008-01-28T10:14:13.330Z
Date de crƩation dans IRIS
2025-05-20T16:14:26Z
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Nom
Naturally_Acquired_MAGE-A10-_and_SSX-2-Specific_CD.pdf
Version du manuscrit
published
Taille
616.31 KB
Format
Adobe PDF
PID Serval
serval:BIB_1874344F750A.P001
URN
urn:nbn:ch:serval-BIB_1874344F750A2
Somme de contrƓle
(MD5):be43f36d088b4f777ff8fbd5fcd5d23b