Titre
Innate Lymphoid Cells in Autoimmune Diseases.
Type
synthèse (review)
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Périodique
Auteur(s)
Clottu, A.S.
Auteure/Auteur
Humbel, M.
Auteure/Auteur
Fluder, N.
Auteure/Auteur
Karampetsou, M.P.
Auteure/Auteur
Comte, D.
Auteure/Auteur
Liens vers les personnes
Liens vers les unités
ISSN
1664-3224
Statut éditorial
Publié
Date de publication
2021
Volume
12
Première page
789788
Peer-reviewed
Oui
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Review
Publication Status: epublish
Publication Status: epublish
Résumé
Innate lymphoid cells (ILC) are a heterogeneous group of immune cells characterized by lymphoid morphology and cytokine profile similar to T cells but which do not express clonally distributed diverse antigen receptors. These particular cells express transcription factors and cytokines reflecting their similarities to T helper (Th)1, Th2, and Th17 cells and are therefore referred to as ILC1, ILC2, and ILC3. Other members of the ILC subsets include lymphoid tissue inducer (LTi) and regulatory ILC (ILCreg). Natural killer (NK) cells share a common progenitor with ILC and also exhibit a lymphoid phenotype without antigen specificity. ILC are found in low numbers in peripheral blood but are much more abundant at barrier sites such as the skin, liver, airways, lymph nodes, and the gastrointestinal tract. They play an important role in innate immunity due to their capacity to respond rapidly to pathogens through the production of cytokines. Recent evidence has shown that ILC also play a key role in autoimmunity, as alterations in their number or function have been identified in systemic lupus erythematosus, systemic sclerosis, and rheumatoid arthritis. Here, we review recent advances in the understanding of the role of ILC in the pathogenesis of autoimmune diseases, with particular emphasis on their role as a potential diagnostic biomarker and as therapeutic targets.
Sujets
PID Serval
serval:BIB_2DE35917C405
PMID
Open Access
Oui
Date de création
2022-01-31T09:33:25.439Z
Date de création dans IRIS
2025-05-20T18:51:07Z
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Nom
fimmu-12-789788 (2).pdf
Version du manuscrit
published
Licence
https://creativecommons.org/licenses/by/4.0
Taille
2.39 MB
Format
Adobe PDF
PID Serval
serval:BIB_2DE35917C405.P001
URN
urn:nbn:ch:serval-BIB_2DE35917C4056
Somme de contrôle
(MD5):0fc73b6e881fb5d0d1097ec1a8293b22