Titre
Intrathecal Drug Delivery: Advances and Applications in the Management of Chronic Pain Patient.
Type
synthèse (review)
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Périodique
Auteur(s)
De Andres, J.
Auteure/Auteur
Hayek, S.
Auteure/Auteur
Perruchoud, C.
Auteure/Auteur
Lawrence, M.M.
Auteure/Auteur
Reina, M.A.
Auteure/Auteur
De Andres-Serrano, C.
Auteure/Auteur
Rubio-Haro, R.
Auteure/Auteur
Hunt, M.
Auteure/Auteur
Yaksh, T.L.
Auteure/Auteur
Liens vers les personnes
Liens vers les unités
ISSN
2673-561X
Statut éditorial
Publié
Date de publication
2022
Volume
3
Première page
900566
Peer-reviewed
Oui
Langue
anglais
Notes
Publication types: Journal Article ; Review
Publication Status: epublish
Publication Status: epublish
Résumé
Advances in our understanding of the biology of spinal systems in organizing and defining the content of exteroceptive information upon which higher centers define the state of the organism and its role in the regulation of somatic and automatic output, defining the motor response of the organism, along with the unique biology and spatial organization of this space, have resulted in an increased focus on therapeutics targeted at this extracranial neuraxial space. Intrathecal (IT) drug delivery systems (IDDS) are well-established as an effective therapeutic approach to patients with chronic non-malignant or malignant pain and as a tool for management of patients with severe spasticity and to deliver therapeutics that address a myriad of spinal pathologies. The risk to benefit ratio of IDD makes it a useful interventional approach. While not without risks, this approach has a significant therapeutic safety margin when employed using drugs with a validated safety profile and by skilled practioners. The present review addresses current advances in our understanding of the biology and dynamics of the intrathecal space, therapeutic platforms, novel therapeutics, delivery technology, issues of safety and rational implementation of its therapy, with a particular emphasis upon the management of pain.
PID Serval
serval:BIB_259C6A6B274D
PMID
Open Access
Oui
Date de création
2022-07-12T09:26:04.049Z
Date de création dans IRIS
2025-05-20T15:50:36Z
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En cours de chargement...
Nom
35782225_BIB_259C6A6B274D.pdf
Version du manuscrit
published
Licence
https://creativecommons.org/licenses/by/4.0
Taille
5.89 MB
Format
Adobe PDF
PID Serval
serval:BIB_259C6A6B274D.P001
URN
urn:nbn:ch:serval-BIB_259C6A6B274D5
Somme de contrôle
(MD5):c0ddf5bbe744778cab14bc0a47830055