Titre
The Diagnostic Performance of 2-[18F]FDG PET/CT in Identifying Richter Transformation in Chronic Lymphocytic Leukemia: An Updated Systematic Review and Bivariate Meta-Analysis.
Type
article
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Périodique
Auteur(s)
Albano, D.
Auteure/Auteur
Rizzo, A.
Auteure/Auteur
Racca, M.
Auteure/Auteur
Muoio, B.
Auteure/Auteur
Bertagna, F.
Auteure/Auteur
Treglia, G.
Auteure/Auteur
Liens vers les personnes
Liens vers les unités
ISSN
2072-6694
Statut éditorial
Publié
Date de publication
2024-05-05
Volume
16
Numéro
9
Peer-reviewed
Oui
Langue
anglais
Notes
Publication types: Journal Article ; Review
Publication Status: epublish
Publication Status: epublish
Résumé
Richter transformation is a rare phenomenon characterized by the transformation of cell chronic lymphocytic leukemia (CLL) into a more aggressive lymphoma variant. The early identification of CLLs with a high risk of RT is fundamental. In this field, 2-deoxy-2-[ <sup>18</sup> F]-fluoro-D-glucose positron emission tomography/computed tomography (2-[ <sup>18</sup> F]FDG PET/CT) has been shown to be a non-invasive and promising tool, but apparently, unclear data seem to be present in the literature. This systematic review and bivariate meta-analysis aimed to investigate the diagnostic performance of 2-[ <sup>18</sup> F]FDG PET/CT and its parameters in predicting RT. Between 2006 and 2024, 15 studies were published on this topic, including 1593 CLL patients. Among semiquantitative variables, SUV <sub>max</sub> was the most investigated, and the best threshold derived for detecting RT was five. With this cut-off value, a pooled sensitivity of 86.8% (95% CI: 78.5-93.3), a pooled specificity of 48.1% (95% CI: 27-69.9), a pooled negative predictive value of 90.5% (95% CI: 88.4-92.4), a pooled negative likelihood ratio of 0.35 (95% CI: 0.17-0.70), a pooled positive likelihood ratio of 1.8 (95% CI: 1.3-2.4), and a pooled diagnostic odds ratio of 6.7 (3.5-12.5) were obtained. With a higher cut-off (SUV <sub>max</sub> = 10), the specificity increased while the sensitivity reduced. The other metabolic features, like metabolic tumor volume, total lesion glycolysis, and radiomic features, were only marginally investigated with controversial evidence.
PID Serval
serval:BIB_89789D021BFC
PMID
Open Access
Oui
Date de création
2024-05-16T13:31:42.308Z
Date de création dans IRIS
2025-05-20T22:03:20Z
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Nom
38730730.pdf
Version du manuscrit
published
Licence
https://creativecommons.org/licenses/by/4.0
Taille
3.16 MB
Format
Adobe PDF
PID Serval
serval:BIB_89789D021BFC.P001
URN
urn:nbn:ch:serval-BIB_89789D021BFC4
Somme de contrôle
(MD5):959a064f6e1f4e9d38284eb11fc09b27