Titre
New pool of cortical interneuron precursors in the early postnatal dorsal white matter.
Type
article
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Périodique
Auteur(s)
Riccio, O.
Auteure/Auteur
Murthy, S.
Auteure/Auteur
Szabo, G.
Auteure/Auteur
Vutskits, L.
Auteure/Auteur
Kiss, J.Z.
Auteure/Auteur
Vitalis, T.
Auteure/Auteur
Lebrand, C.
Auteure/Auteur
Dayer, A.G.
Auteure/Auteur
Liens vers les personnes
Liens vers les unités
ISSN
1460-2199
Statut éditorial
Publié
Date de publication
2012
Volume
22
Numéro
1
Première page
86
Dernière page/numéro d’article
98
Peer-reviewed
Oui
Langue
anglais
Résumé
The migration of cortical γ-aminobutyric acidergic interneurons has been extensively studied in rodent embryos, whereas few studies have documented their postnatal migration. Combining in vivo analysis together with time-lapse imaging on cortical slices, we explored the origin and migration of cortical interneurons during the first weeks of postnatal life. Strikingly, we observed that a large pool of GAD65-GFP-positive cells accumulate in the dorsal white matter region during the first postnatal week. Part of these cells divides and expresses the transcription factor paired box 6 indicating the presence of local transient amplifying precursors. The vast majority of these cells are immature interneurons expressing the neuronal marker doublecortin and partly the calcium-binding protein calretinin. Time-lapse imaging reveals that GAD65-GFP-positive neurons migrate from the white matter pool into the overlying anterior cingulate cortex (aCC). Some interneurons in the postnatal aCC express the same immature neuronal markers suggesting ongoing migration of calretinin-positive interneurons. Finally, bromodeoxyuridine incorporation experiments confirm that a small fraction of interneurons located in the aCC are generated during the early postnatal period. These results altogether reveal that at postnatal ages, the dorsal white matter contains a pool of interneuron precursors that divide and migrate into the aCC.
PID Serval
serval:BIB_F48D15868993
PMID
Open Access
Oui
Date de création
2012-01-27T06:57:59.069Z
Date de création dans IRIS
2025-05-21T06:25:39Z
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Nom
BIB_F48D15868993.P001.pdf
Version du manuscrit
postprint
Taille
4.48 MB
Format
Adobe PDF
PID Serval
serval:BIB_F48D15868993.P001
URN
urn:nbn:ch:serval-BIB_F48D158689936
Somme de contrôle
(MD5):2adaf2a04b782d40a5b4e9bbcc4d87fa