Titre
Population-level risks of alcohol consumption by amount, geography, age, sex, and year: a systematic analysis for the Global Burden of Disease Study 2020.
Type
article
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Périodique
Auteur(s)
Bryazka, D.
Auteure/Auteur
Contributrices/contributeurs
Reitsma, M.B.
Griswold, M.G.
Abate, K.H.
Abbafati, C.
Abbasi-Kangevari, M.
Abbasi-Kangevari, Z.
Abdoli, A.
Abdollahi, M.
Abdullah, AYM
Abhilash, E.S.
Abu-Gharbieh, E.
Acuna, J.M.
Addolorato, G.
Adebayo, O.M.
Adekanmbi, V.
Adhikari, K.
Adhikari, S.
Adnani, QES
Afzal, S.
Agegnehu, W.Y.
Aggarwal, M.
Ahinkorah, B.O.
Ahmad, A.R.
Ahmad, S.
Ahmad, T.
Ahmadi, A.
Ahmadi, S.
Ahmed, H.
Ahmed Rashid, T.
Akunna, C.J.
Al Hamad, H.
Alam, M.Z.
Alem, D.T.
Alene, K.A.
Alimohamadi, Y.
Alizadeh, A.
Allel, K.
Alonso, J.
Alvand, S.
Alvis-Guzman, N.
Amare, F.
Ameyaw, E.K.
Amiri, S.
Ancuceanu, R.
Anderson, J.A.
Andrei, C.L.
Andrei, T.
Arabloo, J.
Arshad, M.
Artamonov, A.A.
Aryan, Z.
Asaad, M.
Asemahagn, M.A.
Astell-Burt, T.
Athari, S.S.
Atnafu, D.D.
Atorkey, P.
Atreya, A.
Ausloos, F.
Ausloos, M.
Ayano, G.
Ayanore, MAA
Ayinde, O.O.
Ayuso-Mateos, J.L.
Azadnajafabad, S.
Azanaw, M.M.
Azangou-Khyavy, M.
Azari Jafari, A.
Azzam, A.Y.
Badiye, A.D.
Bagheri, N.
Bagherieh, S.
Bairwa, M.
Bakkannavar, S.M.
Bakshi, R.K.
Balchut, A.H.
Bärnighausen, T.W.
Barra, F.
Barrow, A.
Baskaran, P.
Belo, L.
Bennett, D.A.
Benseñor, I.M.
Bhagavathula, A.S.
Bhala, N.
Bhalla, A.
Bhardwaj, N.
Bhardwaj, P.
Bhaskar, S.
Bhattacharyya, K.
Bhojaraja, V.S.
Bintoro, B.S.
Blokhina, EAE
Bodicha, BBA
Boloor, A.
Bosetti, C.
Braithwaite, D.
Brenner, H.
Briko, N.I.
Brunoni, A.R.
Butt, Z.A.
Cao, C.
Cao, Y.
Cárdenas, R.
Carvalho, A.F.
Carvalho, M.
Castaldelli-Maia, J.M.
Castelpietra, G.
Castro-de-Araujo, LFS
Cattaruzza, M.S.
Chakraborty, P.A.
Charan, J.
Chattu, V.K.
Chaurasia, A.
Cherbuin, N.
Chu, D.T.
Chudal, N.
Chung, S.C.
Churko, C.
Ciobanu, L.G.
Cirillo, M.
Claro, R.M.
Costanzo, S.
Cowden, R.G.
Criqui, M.H.
Cruz-Martins, N.
Culbreth, G.T.
Dachew, B.A.
Dadras, O.
Dai, X.
Damiani, G.
Dandona, L.
Dandona, R.
Daniel, B.D.
Danielewicz, A.
Darega Gela, J.
Davletov, K.
de Araujo, JAP
de Sá-Junior, A.R.
Debela, S.A.
Dehghan, A.
Demetriades, A.K.
Derbew Molla, M.
Desai, R.
Desta, A.A.
Dias da Silva, D.
Diaz, D.
Digesa, L.E.
Diress, M.
Dodangeh, M.
Dongarwar, D.
Dorostkar, F.
Dsouza, H.L.
Duko, B.
Duncan, B.B.
Edvardsson, K.
Ekholuenetale, M.
Elgar, F.J.
Elhadi, M.
Elmonem, M.A.
Endries, A.Y.
Eskandarieh, S.
Etemadimanesh, A.
Fagbamigbe, A.F.
Fakhradiyev, I.R.
Farahmand, F.
Farinha, CSES
Faro, A.
Farzadfar, F.
Fatehizadeh, A.
Fauk, N.K.
Feigin, V.L.
Feldman, R.
Feng, X.
Fentaw, Z.
Ferrero, S.
Ferro Desideri, L.
Filip, I.
Fischer, F.
Francis, J.M.
Franklin, R.C.
Gaal, P.A.
Gad, M.M.
Gallus, S.
Galvano, F.
Ganesan, B.
Garg, T.
Gebrehiwot, MGD
Gebremeskel, T.G.
Gebremichael, M.A.
Gemechu, T.R.
Getacher, L.
Getachew, M.E.
Getachew Obsa, A.
Getie, A.
Ghaderi, A.
Ghafourifard, M.
Ghajar, A.
Ghamari, S.H.
Ghandour, L.A.
Ghasemi Nour, M.
Ghashghaee, A.
Ghozy, S.
Glozah, F.N.
Glushkova, E.V.
Godos, J.
Goel, A.
Goharinezhad, S.
Golechha, M.
Goleij, P.
Golitaleb, M.
Greaves, F.
Grivna, M.
Grosso, G.
Gudayu, T.W.
Gupta, B.
Gupta, R.
Gupta, S.
Gupta, V.B.
Gupta, V.K.
Hafezi-Nejad, N.
Haj-Mirzaian, A.
Hall, B.J.
Halwani, R.
Handiso, T.B.
Hankey, G.J.
Hariri, S.
Haro, J.M.
Hasaballah, A.I.
Hassanian-Moghaddam, H.
Hay, S.I.
Hayat, K.
Heidari, G.
Heidari, M.
Hendrie, D.
Herteliu, C.
Heyi, D.Z.
Hezam, K.
Hlongwa, M.M.
Holla, R.
Hossain, M.M.
Hossain, S.
Hosseini, S.K.
Hosseinzadeh, M.
Hostiuc, M.
Hostiuc, S.
Hu, G.
Huang, J.
Hussain, S.
Ibitoye, S.E.
Ilic, I.M.
Ilic, M.D.
Immurana, M.
Irham, L.M.
Islam, M.M.
Islam, R.M.
Islam, SMS
Iso, H.
Itumalla, R.
Iwagami, M.
Jabbarinejad, R.
Jacob, L.
Jakovljevic, M.
Jamalpoor, Z.
Jamshidi, E.
Jayapal, S.K.
Jayarajah, U.U.
Jayawardena, R.
Jebai, R.
Jeddi, S.A.
Jema, A.T.
Jha, R.P.
Jindal, H.A.
Jonas, J.B.
Joo, T.
Joseph, N.
Joukar, F.
Jozwiak, J.J.
Jürisson, M.
Kabir, A.
Kabthymer, R.H.
Kamble, B.D.
Kandel, H.
Kanno, G.G.
Kapoor, N.
Karaye, I.M.
Karimi, S.E.
Kassa, B.G.
Kaur, R.J.
Kayode, G.A.
Keykhaei, M.
Khajuria, H.
Khalilov, R.
Khan, I.A.
Khan, M.A.
Kim, H.
Kim, J.
Kim, M.S.
Kimokoti, R.W.
Kivimäki, M.
Klymchuk, V.
Knudsen, AKS
Kolahi, A.A.
Korshunov, V.A.
Koyanagi, A.
Krishan, K.
Krishnamoorthy, Y.
Kumar, G.A.
Kumar, N.
Kumar, N.
Lacey, B.
Lallukka, T.
Lasrado, S.
Lau, J.
Lee, S.W.
Lee, W.C.
Lee, Y.H.
Lim, L.L.
Lim, S.S.
Lobo, S.W.
Lopukhov, P.D.
Lorkowski, S.
Lozano, R.
Lucchetti, G.
Madadizadeh, F.
Madureira-Carvalho, Á.M.
Mahjoub, S.
Mahmoodpoor, A.
Mahumud, R.A.
Makki, A.
Malekpour, M.R.
Manjunatha, N.
Mansouri, B.
Mansournia, M.A.
Martinez-Raga, J.
Martinez-Villa, F.A.
Matzopoulos, R.
Maulik, P.K.
Mayeli, M.
McGrath, J.J.
Meena, J.K.
Mehrabi Nasab, E.
Menezes, R.G.
Mensink, GBM
Mentis, A.A.
Meretoja, A.
Merga, B.T.
Mestrovic, T.
Miao Jonasson, J.
Miazgowski, B.
Micheletti Gomide Nogueira de Sá, A.C.
Miller, T.R.
Mini, G.K.
Mirica, A.
Mirijello, A.
Mirmoeeni, S.
Mirrakhimov, E.M.
Misra, S.
Moazen, B.
Mobarakabadi, M.
Moccia, M.
Mohammad, Y.
Mohammadi, E.
Mohammadian-Hafshejani, A.
Mohammed, T.A.
Moka, N.
Mokdad, A.H.
Momtazmanesh, S.
Moradi, Y.
Mostafavi, E.
Mubarik, S.
Mullany, E.C.
Mulugeta, B.T.
Murillo-Zamora, E.
Murray, CJL
Mwita, J.C.
Naghavi, M.
Naimzada, M.D.
Nangia, V.
Nayak, B.P.
Negoi, I.
Negoi, R.I.
Nejadghaderi, S.A.
Nepal, S.
Neupane, SPP
Neupane Kandel, S.
Nigatu, Y.T.
Nowroozi, A.
Nuruzzaman, K.M.
Nzoputam, C.I.
Obamiro, K.O.
Ogbo, F.A.
Oguntade, A.S.
Okati-Aliabad, H.
Olakunde, B.O.
Oliveira, GMM
Omar Bali, A.
Omer, E.
Ortega-Altamirano, D.V.
Otoiu, A.
Otstavnov, S.S.
Oumer, B.
P A, M.
Padron-Monedero, A.
Palladino, R.
Pana, A.
Panda-Jonas, S.
Pandey, A.
Pandey, A.
Pardhan, S.
Parekh, T.
Park, E.K.
Parry, CDH
Pashazadeh Kan, F.
Patel, J.
Pati, S.
Patton, G.C.
Paudel, U.
Pawar, S.
Peden, A.E.
Petcu, I.R.
Phillips, M.R.
Pinheiro, M.
Plotnikov, E.
Pradhan, PMS
Prashant, A.
Quan, J.
Radfar, A.
Rafiei, A.
Raghav, P.R.
Rahimi-Movaghar, V.
Rahman, A.
Rahman, M.M.
Rahman, M.
Rahmani, A.M.
Rahmani, S.
Ranabhat, C.L.
Ranasinghe, P.
Rao, C.R.
Rasali, D.P.
Rashidi, M.M.
Ratan, Z.A.
Rawaf, D.L.
Rawaf, S.
Rawal, L.
Renzaho, AMN
Rezaei, N.
Rezaei, S.
Rezaeian, M.
Riahi, S.M.
Romero-Rodríguez, E.
Roth, G.A.
Rwegerera, G.M.
Saddik, B.
Sadeghi, E.
Sadeghian, R.
Saeed, U.
Saeedi, F.
Sagar, R.
Sahebkar, A.
Sahoo, H.
Sahraian, M.A.
Saif-Ur-Rahman, K.M.
Salahi, S.
Salimzadeh, H.
Samy, A.M.
Sanmarchi, F.
Santric-Milicevic, M.M.
Sarikhani, Y.
Sathian, B.
Saya, G.K.
Sayyah, M.
Schmidt, M.I.
Schutte, A.E.
Schwarzinger, M.
Schwebel, D.C.
Seidu, A.A.
Senthil Kumar, N.
SeyedAlinaghi, S.
Seylani, A.
Sha, F.
Shahin, S.
Shahraki-Sanavi, F.
Shahrokhi, S.
Shaikh, M.A.
Shaker, E.
Shakhmardanov, M.Z.
Shams-Beyranvand, M.
Sheikhbahaei, S.
Sheikhi, R.A.
Shetty, A.
Shetty, J.K.
Shiferaw, D.S.
Shigematsu, M.
Shiri, R.
Shirkoohi, R.
Shivakumar, K.M.
Shivarov, V.
Shobeiri, P.
Shrestha, R.
Sidemo, N.B.
Sigfusdottir, I.D.
Silva, DAS
Silva, NTD
Singh, J.A.
Singh, S.
Skryabin, V.Y.
Skryabina, A.A.
Sleet, D.A.
Solmi, M.
Solomon, Y.
Song, S.
Song, Y.
Sorensen, RJD
Soshnikov, S.
Soyiri, I.N.
Stein, D.J.
Subba, S.H.
Szócska, M.
Tabarés-Seisdedos, R.
Tabuchi, T.
Taheri, M.
Tan, K.K.
Tareke, M.
Tarkang, E.E.
Temesgen, G.
Temesgen, W.A.
Temsah, M.H.
Thankappan, K.R.
Thapar, R.
Thomas, N.K.
Tiruneh, C.
Todorovic, J.
Torrado, M.
Touvier, M.
Tovani-Palone, M.R.
Tran, MTN
Trias-Llimós, S.
Tripathy, J.P.
Vakilian, A.
Valizadeh, R.
Varmaghani, M.
Varthya, S.B.
Vasankari, T.J.
Vos, T.
Wagaye, B.
Waheed, Y.
Walde, M.T.
Wang, C.
Wang, Y.
Wang, Y.P.
Westerman, R.
Wickramasinghe, N.D.
Wubetu, A.D.
Xu, S.
Yamagishi, K.
Yang, L.
Yesera, GEE
Yigit, A.
Yiğit, V.
Yimaw, AEAE
Yon, D.K.
Yonemoto, N.
Yu, C.
Zadey, S.
Zahir, M.
Zare, I.
Zastrozhin, M.S.
Zastrozhina, A.
Zhang, Z.J.
Zhong, C.
Zmaili, M.
Zuniga, YMH
Gakidou, E.
Groupes de travail
GBD 2020 Alcohol Collaborators
Liens vers les unités
ISSN
1474-547X
Statut éditorial
Publié
Date de publication
2022-07-16
Volume
400
Numéro
10347
Première page
185
Dernière page/numéro d’article
235
Peer-reviewed
Oui
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Publication Status: ppublish
Résumé
The health risks associated with moderate alcohol consumption continue to be debated. Small amounts of alcohol might lower the risk of some health outcomes but increase the risk of others, suggesting that the overall risk depends, in part, on background disease rates, which vary by region, age, sex, and year.
For this analysis, we constructed burden-weighted dose-response relative risk curves across 22 health outcomes to estimate the theoretical minimum risk exposure level (TMREL) and non-drinker equivalence (NDE), the consumption level at which the health risk is equivalent to that of a non-drinker, using disease rates from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2020 for 21 regions, including 204 countries and territories, by 5-year age group, sex, and year for individuals aged 15-95 years and older from 1990 to 2020. Based on the NDE, we quantified the population consuming harmful amounts of alcohol.
The burden-weighted relative risk curves for alcohol use varied by region and age. Among individuals aged 15-39 years in 2020, the TMREL varied between 0 (95% uncertainty interval 0-0) and 0·603 (0·400-1·00) standard drinks per day, and the NDE varied between 0·002 (0-0) and 1·75 (0·698-4·30) standard drinks per day. Among individuals aged 40 years and older, the burden-weighted relative risk curve was J-shaped for all regions, with a 2020 TMREL that ranged from 0·114 (0-0·403) to 1·87 (0·500-3·30) standard drinks per day and an NDE that ranged between 0·193 (0-0·900) and 6·94 (3·40-8·30) standard drinks per day. Among individuals consuming harmful amounts of alcohol in 2020, 59·1% (54·3-65·4) were aged 15-39 years and 76·9% (73·0-81·3) were male.
There is strong evidence to support recommendations on alcohol consumption varying by age and location. Stronger interventions, particularly those tailored towards younger individuals, are needed to reduce the substantial global health loss attributable to alcohol.
Bill & Melinda Gates Foundation.
For this analysis, we constructed burden-weighted dose-response relative risk curves across 22 health outcomes to estimate the theoretical minimum risk exposure level (TMREL) and non-drinker equivalence (NDE), the consumption level at which the health risk is equivalent to that of a non-drinker, using disease rates from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2020 for 21 regions, including 204 countries and territories, by 5-year age group, sex, and year for individuals aged 15-95 years and older from 1990 to 2020. Based on the NDE, we quantified the population consuming harmful amounts of alcohol.
The burden-weighted relative risk curves for alcohol use varied by region and age. Among individuals aged 15-39 years in 2020, the TMREL varied between 0 (95% uncertainty interval 0-0) and 0·603 (0·400-1·00) standard drinks per day, and the NDE varied between 0·002 (0-0) and 1·75 (0·698-4·30) standard drinks per day. Among individuals aged 40 years and older, the burden-weighted relative risk curve was J-shaped for all regions, with a 2020 TMREL that ranged from 0·114 (0-0·403) to 1·87 (0·500-3·30) standard drinks per day and an NDE that ranged between 0·193 (0-0·900) and 6·94 (3·40-8·30) standard drinks per day. Among individuals consuming harmful amounts of alcohol in 2020, 59·1% (54·3-65·4) were aged 15-39 years and 76·9% (73·0-81·3) were male.
There is strong evidence to support recommendations on alcohol consumption varying by age and location. Stronger interventions, particularly those tailored towards younger individuals, are needed to reduce the substantial global health loss attributable to alcohol.
Bill & Melinda Gates Foundation.
PID Serval
serval:BIB_DCBAB64345ED
PMID
Open Access
Oui
Date de création
2022-10-04T10:19:21.398Z
Date de création dans IRIS
2025-05-21T07:05:39Z
Fichier(s)![Vignette d'image]()
En cours de chargement...
Nom
35843246_BIB_DCBAB64345ED.pdf
Version du manuscrit
published
Taille
5.51 MB
Format
Adobe PDF
PID Serval
serval:BIB_DCBAB64345ED.P001
Somme de contrôle
(MD5):83997e0f5b1ea3f81f704cb0a6372388