Titre
Effect of sodium intake on gene expression and plasma levels of ANF in rats.
Type
article
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Auteur(s)
Lattion, A.L.
Auteure/Auteur
Aubert, J.F.
Auteure/Auteur
Flückiger, J.P.
Auteure/Auteur
Nussberger, J.
Auteure/Auteur
Waeber, B.
Auteure/Auteur
Brunner, H.R.
Auteure/Auteur
Liens vers les personnes
Liens vers les unités
ISSN
0363-6135
Statut éditorial
Publié
Date de publication
1988
Volume
255
Numéro
2 Pt 2
Première page
H245
Dernière page/numéro d’article
H249
Langue
anglais
Notes
Journal Article Research Support, Non-U.S. Gov't --- Old month value: Aug
Résumé
The effect of short- and long-term sodium loading and sodium restriction on the gene expression as well as on circulating plasma levels of atrial natriuretic factor (ANF) was evaluated in normotensive Wistar rats. These rats were fed either a low-, a regular-, or a high-sodium diet (regular diet and 1% saline as drinking fluid) and studied after 1 and 3 wk. The ANF mRNA was determined in pooled atria and ventricles of the different groups of rats, using the dot-blot technique. Plasma ANF levels were measured with a radioimmunoassay. After 1 wk on the high-sodium diet, ANF mRNA was increased in right atria and ventricles together with circulating ANF levels when compared with animals maintained for the same period on a low-sodium diet. After 3 wk on the various diets, the differences in cardiac ANF mRNA and in plasma ANF levels had disappeared. Gene expression of ANF was also looked for in different areas of the brain, lung, thyroid, adrenals, and the kidney; no hybridization was detected in any of these organs. These data suggest that in rats, the transcription of the ANF gene and peptide release in enhanced only during short-term adaptation to dietary sodium loading.
PID Serval
serval:BIB_8475B1ED66B9
PMID
Date de création
2008-03-05T15:39:31.831Z
Date de création dans IRIS
2025-05-21T02:34:40Z