Titre
A siliconized hollow fiber membrane oxygenator
Type
article
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Périodique
Auteur(s)
Mueller, X. M.
Auteure/Auteur
Marty, B.
Auteure/Auteur
Tevaearai, H. T.
Auteure/Auteur
Tozzi, P.
Auteure/Auteur
Jegger, D.
Auteure/Auteur
von Segesser, L. K.
Auteure/Auteur
Liens vers les personnes
Liens vers les unités
ISSN
1058-2916
Statut éditorial
Publié
Date de publication
2000-02
Volume
46
Numéro
1
Première page
38
Dernière page/numéro d’article
41
Notes
Journal Article --- Old month value: Jan-Feb
Résumé
Most membrane oxygenators are built with microporous fibers known for plasma leakage in long-term use such as extracorporeal life support or extracorporeal membrane oxygenation. The current study was designed to evaluate the Quadrox oxygenator in which the fibers have been coated with silicone (Jostra). Six calves (mean weight, 62 +/- 4 kg) were connected to cardiopulmonary bypass (CPB) by jugular venous and carotid arterial cannulation, with a mean flow rate of 3 L/min for 6 hours. They were randomly assigned to a standard Quadrox oxygenator (standard group, n = 3) or a siliconized Quadrox oxygenator (silicone group, n = 3). After 7 days, the animals were sacrificed. A standard battery of blood samples was taken before bypass, after mixing for 10 minutes, and after 1, 2, 5, and 6 hours of perfusion. Analysis of variance was used for repeated measurements. Total oxygen transfer and carbon dioxide transfer did not differ between groups (p = 0.5 for comparison). Blood trauma, evaluated by plasma hemoglobin (Hb), did not detect any significant hemolysis in either group. Thrombocyte and white blood cell count profiles in both groups were parallel and without significant differences (p = 0.1 and 0.6, respectively). At the end of testing no clot deposition was found in the oxygenator. At postmortem, there were no signs of peripheral emboli. The results of this study suggest that this silicone coating of hollow fibers allows for good gas transfer, while preserving all the mechanical advantages of a conventional hollow fiber oxygenator.
Sujets
PID Serval
serval:BIB_BAC3C0FF4681
PMID
Date de création
2008-01-28T08:31:36.239Z
Date de création dans IRIS
2025-05-20T21:19:35Z