Titre
Cerebellar Connectomics Provide New Biomarkers in Early Multiple Sclerosis
Type
article de conférence/colloque
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Auteur(s)
Romascano, David
Auteure/Auteur
Meskaldji, Djalel-Eddine
Auteure/Auteur
Bonnier, Guillaume
Auteure/Auteur
Simioni, Samanta
Auteure/Auteur
Rotzinger, David
Auteure/Auteur
Lin, Ying-Chia
Auteure/Auteur
Menegaz, Gloria
Auteure/Auteur
Roche, Alexis
Auteure/Auteur
Schluep, Myriam
Auteure/Auteur
Pasquier Renaud, Du
Auteure/Auteur
Richiardi, Jonas
Auteure/Auteur
Van De Ville , Dimitri
Auteure/Auteur
Daducci, Alessandro
Auteure/Auteur
Sumpf, Tilman
Auteure/Auteur
Fraham, Jens
Auteure/Auteur
Thiran, Jean-Philippe
Auteure/Auteur
Krueger, Gunnar
Auteure/Auteur
Granziera, Cristina
Auteure/Auteur
Liens vers les personnes
Liens vers les unités
Titre du livre ou conférence/colloque
22nd annual meeting of the International Society for Magnetic Resonance in Medicine (ISMRM)
Statut éditorial
Publié
Date de publication
2014
Notes
EPFL-CONF-211187
Résumé
The cerebellum is involved in multiple sclerosis (MS),
but its implication in early phases is still poorly
understood. We investigated structural and functional
cerebellar connectivity alterations in early and
minimally impaired MS patients, and their correlation to
patientsâeuro™ clinical status. We reconstructed the
connectomes of 28 MS patients and 16 healthy controls and
performed network statistical analysis. Structural
connectivity was found to be altered independently from
cerebellar lesion count, volume and disease duration; the
microstructural properties of altered connections
correlated with patientsâeuro™ motor and cognitive
performance. No topological reorganization or
compensatory mechanisms were observed at this stage.
but its implication in early phases is still poorly
understood. We investigated structural and functional
cerebellar connectivity alterations in early and
minimally impaired MS patients, and their correlation to
patientsâeuro™ clinical status. We reconstructed the
connectomes of 28 MS patients and 16 healthy controls and
performed network statistical analysis. Structural
connectivity was found to be altered independently from
cerebellar lesion count, volume and disease duration; the
microstructural properties of altered connections
correlated with patientsâeuro™ motor and cognitive
performance. No topological reorganization or
compensatory mechanisms were observed at this stage.
PID Serval
serval:BIB_A30B1FAC3C4A
Date de création
2015-11-27T13:13:43.450Z
Date de création dans IRIS
2025-05-20T23:09:47Z