Titre
A direct demonstration of functional specialization in human visual cortex.
Type
article
Institution
Externe
Périodique
Auteur(s)
Zeki, S.
Auteure/Auteur
Watson, J.D.
Auteure/Auteur
Lueck, C.J.
Auteure/Auteur
Friston, K.J.
Auteure/Auteur
Kennard, C.
Auteure/Auteur
Frackowiak, R.S.
Auteure/Auteur
Liens vers les personnes
ISSN
0270-6474
Statut éditorial
Publié
Date de publication
1991
Volume
11
Numéro
3
Première page
641
Dernière page/numéro d’article
649
Langue
anglais
Notes
Publication types: Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov'tPublication Status: ppublish
Résumé
We have used positron emission tomography (PET), which measures regional cerebral blood flow (rCBF), to demonstrate directly the specialization of function in the normal human visual cortex. A novel technique, statistical parametric mapping, was used to detect foci of significant change in cerebral blood flow within the prestriate cortex, in order to localize those parts involved in the perception of color and visual motion. For color, we stimulated the subjects with a multicolored abstract display containing no recognizable objects (Land color Mondrian) and contrasted the resulting blood flow maps with those obtained when subjects viewed an identical display consisting of equiluminous shades of gray. The comparison identified a unique area (area V4) located in the lingual and fusiform gyri of the prestriate cortex. For motion, blood flow maps when subjects viewed moving or stationary black and white random-square patterns were contrasted. The comparison identified a unique area located in the region of the temporo-parieto-occipital junction (area V5). We thus provide direct evidence to show that, just as in the macaque monkey, different areas of the human prestriate visual cortex are specialized for different attributes of vision. The striate cortex (V1) and the contiguous visual area (V2), which in the monkey brain feed both the homologous areas, were active in all 4 conditions. This pattern of activity allowed us to use an extension of the approach to assess the functional relationship between the 3 areas during color and motion stimulation. This is based on an hypothesis-led analysis of the covariance structure of the blood flow maps and promises to be a powerful tool for inferring anatomical pathways in the normal human brain.(ABSTRACT TRUNCATED AT 250 WORDS)
PID Serval
serval:BIB_B02A22090EBF
PMID
Date de création
2011-10-06T16:25:34.756Z
Date de création dans IRIS
2025-05-21T02:49:00Z