Titre
Leukocyte Count and Coronary Artery Disease Events in People With Human Immunodeficiency Virus: A Longitudinal Study.
Type
article
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Périodique
Auteur(s)
Avery, E.F.
Auteure/Auteur
Kleynhans, J.N.
Auteure/Auteur
Ledergerber, B.
Auteure/Auteur
Schoepf, I.C.
Auteure/Auteur
Thorball, C.W.
Auteure/Auteur
Kootstra, N.A.
Auteure/Auteur
Reiss, P.
Auteure/Auteur
Ryom, L.
Auteure/Auteur
Braun, D.L.
Auteure/Auteur
Thurnheer, M.C.
Auteure/Auteur
Marzolini, C.
Auteure/Auteur
Seneghini, M.
Auteure/Auteur
Bernasconi, E.
Auteure/Auteur
Cavassini, M.
Auteure/Auteur
Buvelot, H.
Auteure/Auteur
Kouyos, R.D.
Auteure/Auteur
Fellay, J.
Auteure/Auteur
Günthard, H.F.
Auteure/Auteur
Tarr, P.E.
Auteure/Auteur
Contributrices/contributeurs
Anagnostopoulos, A.
Battegay, M.
Bernasconi, E.
Boni, J.
Braun, D.L.
Bucher, H.C.
Calmy, A.
Cavassini, M.
Ciuffi, A.
Dollenmaier, G.
Egger, M.
Elzi, L.
Fehr, J.
Fellay, J.
Furrer, H.
Fux, C.A.
Gunthard, H.F.
Haerry, D.
Hasse, B.
Hirsch, H.H.
Hoffmann, M.
Hosli, I.
Huber, M.
Kahlert, C.R.
Kaiser, L.
Keiser, O.
Klimkait, T.
Kouyos, R.D.
Kovari, H.
Ledergerber, B.
Martinetti, G.
de Martinez, T.B.
Marzolini, C.
Metzner, K.J.
Muller, N.
Nicca, D.
Paioni, P.
Pantaleo, G.
Perreau, M.
Rauch, A.
Rudin, C.
Scherrer, A.U.
Schmid, P.
Speck, R.
Stockle, M.
Tarr, P.
Trkola, A.
Vernazza, P.
Wandeler, G.
Weber, R.
Yerly, S.
Groupes de travail
Swiss HIV Cohort Study
Liens vers les personnes
Liens vers les unités
ISSN
1537-6591
Statut éditorial
Publié
Date de publication
2023-06-08
Volume
76
Numéro
11
Première page
1969
Dernière page/numéro d’article
1979
Peer-reviewed
Oui
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Publication Status: ppublish
Résumé
People with human immunodeficiency virus (HIV; PWH) have increased cardiovascular risk. Higher leukocyte count has been associated with coronary artery disease (CAD) events in the general population. It is unknown whether the leukocyte-CAD association also applies to PWH.
In a case-control study nested within the Swiss HIV Cohort Study, we obtained uni- and multivariable odds ratios (OR) for CAD events, based on traditional and HIV-related CAD risk factors, leukocyte count, and confounders previously associated with leukocyte count.
We included 536 cases with a first CAD event (2000-2021; median age, 56 years; 87% male; 84% with suppressed HIV RNA) and 1464 event-free controls. Cases had higher latest leukocyte count before CAD event than controls (median [interquartile range], 6495 [5300-7995] vs 5900 [4910-7200]; P < .01), but leukocytosis (>11 000/µL) was uncommon (4.3% vs 2.1%; P = .01). In the highest versus lowest leukocyte quintile at latest time point before CAD event, participants had univariable CAD-OR = 2.27 (95% confidence interval, 1.63-3.15) and multivariable adjusted CAD-OR = 1.59 (1.09-2.30). For comparison, univariable CAD-OR for dyslipidemia, diabetes, and recent abacavir exposure were 1.58 (1.29-1.93), 2.19 (1.59-3.03), and 1.73 (1.37-2.17), respectively. Smoking and, to a lesser degree, alcohol and ethnicity attenuated the leukocyte-CAD association. Leukocytes measured up to 8 years before the event were significantly associated with CAD events.
PWH in Switzerland with higher leukocyte counts have an independently increased risk of CAD events, to a degree similar to traditional and HIV-related risk factors.
In a case-control study nested within the Swiss HIV Cohort Study, we obtained uni- and multivariable odds ratios (OR) for CAD events, based on traditional and HIV-related CAD risk factors, leukocyte count, and confounders previously associated with leukocyte count.
We included 536 cases with a first CAD event (2000-2021; median age, 56 years; 87% male; 84% with suppressed HIV RNA) and 1464 event-free controls. Cases had higher latest leukocyte count before CAD event than controls (median [interquartile range], 6495 [5300-7995] vs 5900 [4910-7200]; P < .01), but leukocytosis (>11 000/µL) was uncommon (4.3% vs 2.1%; P = .01). In the highest versus lowest leukocyte quintile at latest time point before CAD event, participants had univariable CAD-OR = 2.27 (95% confidence interval, 1.63-3.15) and multivariable adjusted CAD-OR = 1.59 (1.09-2.30). For comparison, univariable CAD-OR for dyslipidemia, diabetes, and recent abacavir exposure were 1.58 (1.29-1.93), 2.19 (1.59-3.03), and 1.73 (1.37-2.17), respectively. Smoking and, to a lesser degree, alcohol and ethnicity attenuated the leukocyte-CAD association. Leukocytes measured up to 8 years before the event were significantly associated with CAD events.
PWH in Switzerland with higher leukocyte counts have an independently increased risk of CAD events, to a degree similar to traditional and HIV-related risk factors.
Sujets
PID Serval
serval:BIB_E1546C7A7084
PMID
Open Access
Oui
Date de création
2023-01-31T14:41:02.011Z
Date de création dans IRIS
2025-05-21T06:57:17Z
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Nom
Avery.pdf
Version du manuscrit
published
Licence
https://creativecommons.org/licenses/by/4.0
Taille
1006.36 KB
Format
Adobe PDF
PID Serval
serval:BIB_E1546C7A7084.P001
URN
urn:nbn:ch:serval-BIB_E1546C7A70840
Somme de contrôle
(MD5):4266611f03f191f5d9884fac7db5d329