Titre
Premature ventricular contraction-induced cardiomyopathy: Related clinical and electrophysiologic parameters.
Type
article
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Périodique
Auteur(s)
Sadron Blaye-Felice, M.
Auteure/Auteur
Hamon, D.
Auteure/Auteur
Sacher, F.
Auteure/Auteur
Pascale, P.
Auteure/Auteur
Rollin, A.
Auteure/Auteur
Duparc, A.
Auteure/Auteur
Mondoly, P.
Auteure/Auteur
Derval, N.
Auteure/Auteur
Denis, A.
Auteure/Auteur
Cardin, C.
Auteure/Auteur
Hocini, M.
Auteure/Auteur
Jaïs, P.
Auteure/Auteur
Schlaepfer, J.
Auteure/Auteur
Bongard, V.
Auteure/Auteur
Carrié, D.
Auteure/Auteur
Galinier, M.
Auteure/Auteur
Pruvot, E.
Auteure/Auteur
Lellouche, N.
Auteure/Auteur
Haïssaguerre, M.
Auteure/Auteur
Maury, P.
Auteure/Auteur
Liens vers les personnes
Liens vers les unités
ISSN
1556-3871
Statut éditorial
Publié
Date de publication
2016
Volume
13
Numéro
1
Première page
103
Dernière page/numéro d’article
110
Peer-reviewed
Oui
Langue
anglais
Notes
Publication types: Journal Article ; Observational Study
Publication Status: ppublish
Publication Status: ppublish
Résumé
BACKGROUND: Factors associated with premature ventricular contraction-induced cardiomyopathy (PVCi-CMP) remain debated.
OBJECTIVE: The purpose of this study was to test the correlation of various factors to the presence PVCi-CMP in a large multicenter population.
METHODS: One hundred sixty-eight consecutive patients referred for ablation of frequent premature ventricular contractions (PVCs) were included. Patients were divided into 2 groups: group 1 with suspected PVCi-CMP (96 patients, ejection fraction 38% ± 10%, left ventricular end-diastolic diameter 62 ± 8 mm, with or without additional structural heart disease); and group 2 (control group, 72 patients with normal ejection fraction and left ventricular dimensions). Various clinical and electrophysiologic parameters were compared between groups.
RESULTS: In univariate analysis, left ventricular origin of PVC, lack of palpitations, long PVC coupling interval, epicardial origin of the focus, long sinus beat QRS duration, male gender, high PVC burden, presence of polymorphic PVCs, high PVC QRS duration, and older age were significantly related to the presence of PVCi-CMP. In multivariate analysis, only lack of palpitations, PVC burden, and epicardial origin remained significantly and independently correlated with the presence of cardiomyopathy. Even if sinus QRS duration or PVC left ventricular origin were also found independently linked to PVCi-CMP in the whole population, they were no longer correlated when patients with additional heart disease were excluded.
CONCLUSION: Lack of palpitations, PVC burden, and epicardial origin are independent factors that identify patients prone to developing PVCi-CMP.
OBJECTIVE: The purpose of this study was to test the correlation of various factors to the presence PVCi-CMP in a large multicenter population.
METHODS: One hundred sixty-eight consecutive patients referred for ablation of frequent premature ventricular contractions (PVCs) were included. Patients were divided into 2 groups: group 1 with suspected PVCi-CMP (96 patients, ejection fraction 38% ± 10%, left ventricular end-diastolic diameter 62 ± 8 mm, with or without additional structural heart disease); and group 2 (control group, 72 patients with normal ejection fraction and left ventricular dimensions). Various clinical and electrophysiologic parameters were compared between groups.
RESULTS: In univariate analysis, left ventricular origin of PVC, lack of palpitations, long PVC coupling interval, epicardial origin of the focus, long sinus beat QRS duration, male gender, high PVC burden, presence of polymorphic PVCs, high PVC QRS duration, and older age were significantly related to the presence of PVCi-CMP. In multivariate analysis, only lack of palpitations, PVC burden, and epicardial origin remained significantly and independently correlated with the presence of cardiomyopathy. Even if sinus QRS duration or PVC left ventricular origin were also found independently linked to PVCi-CMP in the whole population, they were no longer correlated when patients with additional heart disease were excluded.
CONCLUSION: Lack of palpitations, PVC burden, and epicardial origin are independent factors that identify patients prone to developing PVCi-CMP.
PID Serval
serval:BIB_A75241652F1D
PMID
Date de création
2016-03-10T14:32:04.429Z
Date de création dans IRIS
2025-05-20T23:13:29Z
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Version du manuscrit
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