Titre
Das primare synoviale Sarkom der Niere. Eine neue Entitat im morphologischen Spektrum der spindelzellig differenzierten Nierentumoren [Primary renal synovial sarcoma. A new entity in the morphological spectrum of spindle cell renal tumors]
Type
étude de cas
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Périodique
Der Pathologe
Auteur(s)
Moch, H.
Auteure/Auteur
Wodzynski, A.
Auteure/Auteur
Guillou, L.
Auteure/Auteur
Nickeleit, V.
Auteure/Auteur
Liens vers les personnes
Liens vers les unités
ISSN
0172-8113
Statut éditorial
Publié
Date de publication
2003
Volume
24
Numéro
6
Première page
466
Dernière page/numéro d’article
472
Notes
PT - Case Reports PT - English Abstract PT - Journal Article PT - Review
Résumé
We report 2 primary renal synovial sarcoma. These tumors were formerly designated as embryonal cystic sarcoma of the kidney. Most cases are diagnosed between the ages of 20 and 50 years. Some cases show local recurrence after nephrectomy. On gross examination, tumors are large, partially necrotic, and usually contain cysts. Microscopically, tumors are characterized by monomorphic plump spindle cells. The cysts are lined by mitotically inactive epithelial cells without striking cellular atypia. The spindle cells were immunoreactive for EMA, CD56, and sometimes for CD99. They were non-reactive for desmin, actin, S 100, and cytokeratins. The cyst epithelium is cytokeratin positive. The presence of a SYT-SSX gene fusion resulting from the t(X;18) characteristic for synovial sarcoma was demonstrated by reverse transcriptase polymerase chain reaction in both tumors. Primary renal synovial sarcoma is a distinctive tumor entity, which should be considered in renal tumors consisting of spindle cells
Sujets
PID Serval
serval:BIB_6BA6F04D5A7F
PMID
Date de création
2008-01-29T17:36:10.300Z
Date de création dans IRIS
2025-05-21T03:33:58Z