Titre
Effect of different hormonal replacement therapies on circulating allopregnanolone and dehydroepiandrosterone levels in postmenopausal women.
Type
article
Institution
Externe
Périodique
Auteur(s)
Bernardi, F.
Auteure/Auteur
Pieri, M.
Auteure/Auteur
Stomati, M.
Auteure/Auteur
Luisi, S.
Auteure/Auteur
Palumbo, M.
Auteure/Auteur
Pluchino, N.
Auteure/Auteur
Ceccarelli, C.
Auteure/Auteur
Genazzani, A.R.
Auteure/Auteur
Liens vers les personnes
ISSN
0951-3590
Statut éditorial
Publié
Date de publication
2003-02
Volume
17
Numéro
1
Première page
65
Dernière page/numéro d’article
77
Peer-reviewed
Oui
Langue
anglais
Notes
Publication types: Clinical Trial ; Journal Article ; Randomized Controlled Trial
Publication Status: ppublish
Publication Status: ppublish
Résumé
The effects of hormone replacement therapy (HRT) on the central nervous system in postmenopausal women might be mediated by changes in neurosteroid synthesis and/or release. The aim of this study was to evaluate the impact of HRT on the levels of allopregnanolone, a sedative anxiolytic GABA(A) agonist steroid, and dehydroepiandrosterone (DHEA), a GABA(A) antagonist steroid. We evaluated allopregnanolone and DHEA circulating levels after 1, 3, 6, 9 and 12 months of HRT with ten different estrogen or estrogen-progestin molecules, regimens and routes of administration in 186 postmenopausal women. Cortisol, luteinizing hormone, follicle stimulating hormone, estradiol and progesterone levels were also evaluated. Allopregnanolone levels significantly increased during follow-up with all HRT preparations. The addition of progestin molecules (except for 19-nor derivatives) to transdermal estradiol administration alone determined a higher increase in allopregnanolone levels. Transdermal HRT showed a significantly higher percentage change in allopregnanolone levels compared with oral HRT. DHEA levels showed a progressive decline starting from the 3-month follow-up, without significant differences between the transdermal and oral groups, as well as among the ten groups, independently of the presence and type of progestin molecule used. In conclusion, HRT strongly modifies circulating neurosteroid levels in postmenopausal women.
PID Serval
serval:BIB_7D3F85CCBF37
PMID
Date de création
2023-09-15T11:25:07.162Z
Date de création dans IRIS
2025-05-21T04:10:33Z