Titre
Leu-8/TQ1 is the human equivalent of the Mel-14 lymph node homing receptor.
Type
article
Institution
Externe
Périodique
Auteur(s)
Camerini, D.
Auteure/Auteur
James, S.P.
Auteure/Auteur
Stamenkovic, I.
Auteure/Auteur
Seed, B.
Auteure/Auteur
Liens vers les personnes
ISSN
0028-0836[print], 0028-0836[linking]
Statut éditorial
Publié
Date de publication
1989
Volume
342
Numéro
6245
Première page
78
Dernière page/numéro d’article
82
Langue
anglais
Notes
Publication types: Comparative Study ; Journal Article
Résumé
The human pan-leukocyte antigen Leu-8 has attracted wide interest because its presence or absence identifies suppressor-inducer and helper-inducer CD4+ T-lymphocyte subsets respectively. We report here that Leu-8 is the human homologue of the mouse Mel-14 homing receptor, a molecule that promotes the initial adhesion of blood-borne lymphocytes to the specialized post-capillary endothelium of peripheral lymph nodes. We also show that Leu-8 can adopt both conventional and phospholipid anchored forms, a finding that may have relevance in the context of antigen shedding following activation or homing. The assignment of lymphocytes to different functional classes based on lymph node homing potential may represent a more general association between lymphocyte function and tissue distribution.
Sujets
PID Serval
serval:BIB_EF01B5B4E98E
PMID
Date de création
2010-08-25T13:59:06.145Z
Date de création dans IRIS
2025-05-21T03:07:45Z