Titre
Removal of pharmaceuticals from human urine during storage, aerobic biological treatment, and activated carbon adsorption to produce a safe fertilizer
Type
article
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Périodique
Auteur(s)
Özel Duygan, Birge D.
Auteure/Auteur
Udert, Kai M.
Auteure/Auteur
Remmele, Annette
Auteure/Auteur
McArdell, Christa S.
Auteure/Auteur
Liens vers les unités
ISSN
0921-3449
Statut éditorial
Publié
Date de publication
2021-03
Volume
166
Première page
105341
Langue
anglais
Résumé
Urine has great potential to be an effective fertilizer due to its high nutrient content, however, it can contain potentially worrying pharmaceuticals. Our objective was to study whether urine storage and aerobic biological treatment, i.e. nitrification, was sufficient to remove pharmaceuticals or an additional treatment with activated carbon was necessary to produce a fertilizer from urine. We investigated the abatement of twelve pharmaceuticals, including antibiotics and antivirals, in laboratory experiments representing the treatment steps of anaerobic storage of source-separated human urine, stabilization using partial and full nitrification under acclimatized and non-acclimatized conditions, and treatment of nitrified urine using powdered activated carbon (PAC). Two-month-long-term storage of urine was insufficient to substantially degrade the pharmaceuticals, except for hydrochlorothiazide (>90%). In the partial and full nitrification fed-batch reactors, atazanavir, ritonavir, and clarithromycin were rapidly removed, with biotransformation rate constants greater than 10 L(gss)(-1)d(-1). Darunavir, emtricitabine, trimethoprim, N4-acetylsulfamethoxazole, sulfamethoxazole, atenolol, diclofenac, and hydrochlorothiazide were degraded slowly, with biotransformation rate constants of < 1 L(gss)(-1)d(-1). With 200 mg PAC L-1, at least 90% of each investigated pharmaceutical was removed. Yeast estrogen screen tests and bioluminescence inhibition tests revealed efficient removal of estrogenicity (99%) and toxicity (56%) using nitrification, and a reduction of 89% and 64%, respectively, using 200 mg PAC L-1. With our study, we provide biotransformation rate constants of compounds never previously investigated. We also show that a combination of nitrification and PAC adsorption enables the production of a safe fertilizer with sufficiently low pharmaceutical concentrations and no removal of beneficial nutrients.
PID Serval
serval:BIB_BC2D5D5BB6EE
Open Access
Oui
Date de création
2021-02-15T09:10:52.972Z
Date de création dans IRIS
2025-05-21T04:54:29Z
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Nom
Removal of pharmaceuticals from human urine during storage, aerobic biological treatment, and activated carbon adsorption to produce a safe fertilizer.pdf
Version du manuscrit
published
Licence
https://creativecommons.org/licenses/by/4.0
Taille
2.3 MB
Format
Adobe PDF
PID Serval
serval:BIB_BC2D5D5BB6EE.P001
URN
urn:nbn:ch:serval-BIB_BC2D5D5BB6EE4
Somme de contrôle
(MD5):9fd6cde47b6cd54e0589a7f6efed38ab