Titre

Longitudinal Bone Loss Occurs at the Radius in CKD.

Type
article
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Périodique
Auteur(s)
Cailleaux, P.E.
Auteure/Auteur
Ostertag, A.
Auteure/Auteur
Metzger, M.
Auteure/Auteur
Stengel, B.
Auteure/Auteur
Boucquemont, J.
Auteure/Auteur
Houillier, P.
Auteure/Auteur
Flamant, M.
Auteure/Auteur
Ureña-Torres, P.
Auteure/Auteur
Cohen-Solal, M.
Auteure/Auteur
Contributrices/contributeurs
Letavernier, E.
Ronco, P.
Fessi, H.
Daugas, E.
du Halgouet, C.
de La Faille, R.
d'Auzac, C.
Maruani, G.
Vallet, M.
Gauci, C.
Haymann, J.P.
Thervet, E.
Boffa, J.J.
Vrtovsnik, F.
Froissart, M.
Stengel, B.
Nicolet-Barousse, L.
Roland, M.
Jacquot, C.
Groupes de travail
NephroTest Study group
Liens vers les personnes
Liens vers les unités
ISSN
2468-0249
Statut éditorial
Publié
Date de publication
2021-06
Volume
6
Numéro
6
Première page
1525
Dernière page/numéro d’article
1536
Peer-reviewed
Oui
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: epublish
Résumé
Chronic kidney disease (CKD) exposes to an increased incidence of fragility fractures. International guidelines recommend performing bone mineral density (BMD) if the results will impact treatment decisions. It remains unknown where bone loss occurs and what would preclude the longitudinal loss in patients with CKD. Here, we aimed to investigate factors influencing BMD and to analyze the longitudinal BMD changes.
In the NephroTest cohort, we measured BMD at the femoral neck, total hip, lumbar spine, and proximal radius, together with circulating biomarkers and standardized measured glomerular filtration rate (mGFR) by <sup>51</sup> Cr-EDTA in a subset of patients with CKD stage 1 to 5 followed during 4.3 ± 2.0 years. A linear mixed model explored the longitudinal bone loss and the relationship of associated factors with BMD changes. A total of 858 patients (mean age 58.9 ± 15.2 years) had at least 1 and 477 had at least 2 BMD measures.
At baseline, cross-sectional analysis showed a significantly lower BMD at femoral neck and total hip and a significant higher serum parathyroid hormone (PTH) along with CKD stages. Baseline age, gender, tobacco, low body mass index (BMI), and high PTH levels were significantly associated with low BMD. Longitudinal analysis during the mean 4.3 years revealed a significant bone loss at the radius only. BMD changes at the femoral neck were associated with BMI, but not CKD stages or basal PTH levels.
CKD is associated with low BMD and high PTH in the cross-sectional analysis. Longitudinal bone loss occurred at the proximal radius after 4.3 years.
Sujets

bone mineral density

chronic kidney diseas...

fracture

osteoporosis

parathyroid hormone

PID Serval
serval:BIB_AB144E9576D9
DOI
PMID
WOS
Permalien
URL éditeur
Open Access
Oui
Date de création
2021-09-06T09:29:01.599Z
Date de création dans IRIS
2025-05-21T04:57:36Z
Fichier(s)
En cours de chargement...
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Nom

Cailleaux Longitudinal bone loss occurs at the radius in CKD KI Reports 2021.pdf

Version du manuscrit

published

Licence

https://creativecommons.org/licenses/by-nc-nd/4.0

Taille

297.33 KB

Format

Adobe PDF

PID Serval

serval:BIB_AB144E9576D9.P001

URN

urn:nbn:ch:serval-BIB_AB144E9576D95

Somme de contrôle

(MD5):e43185b76faaa3df7035f7f775676d6c

En cours de chargement...
Vignette d'image
Nom

Cailleaux Longitudinal bone loss occurs at the radius in CKD Suppl data KI Reports 2021.pdf

Version du manuscrit

supplementary

Taille

854.33 KB

Format

Adobe PDF

PID Serval

serval:BIB_AB144E9576D9.S001

Somme de contrôle

(MD5):dc74b7435013e182c0c84cc0af2af0c7