Titre
Complications neuro-ophtalmologiques du lupus erythemateux dissemine. [Neuro-ophthalmologic complications of disseminated lupus erythematosus]
Type
étude de cas
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Périodique
Auteur(s)
Borruat, F. X.
Auteure/Auteur
Prado, T.
Auteure/Auteur
Strominger, M.
Auteure/Auteur
Schatz, N. J.
Auteure/Auteur
Glaser, J. S.
Auteure/Auteur
Liens vers les personnes
Liens vers les unités
ISSN
0023-2165
Statut éditorial
Publié
Date de publication
1994-05
Volume
204
Numéro
5
Première page
403
Dernière page/numéro d’article
6
Notes
Case Reports
English Abstract
Journal Article --- Old month value: May
English Abstract
Journal Article --- Old month value: May
Résumé
BACKGROUND: Systemic lupus erythematosus (SLE) is a multisystemic inflammatory disease of unknown etiology. Physiopathology includes small vessel occlusion and auto-antibody production. Neuro-ophthalmic complications can be detected in 10-30% of SLE cases. Further, some patients can present with neuro-ophthalmic complications prior to diagnosis of SLE. PATIENTS AND METHODS: We report seven cases of neuro-ophthalmic complications of SLE demonstrating lesions from the retina to the brain. The other possible manifestations of SLE will be reviewed. RESULTS: Two cases were not yet diagnosed with SLE when neuro-ophthalmic disease occurred. Anti-double stranded DNA antibodies were detected at a very high titer, suggesting SLE, later confirmed by rheumatologists. CONCLUSIONS: Ophthalmologists should be aware of the unusual patient presenting with a neuroophthalmic disorder prior to the diagnosis of SLE. In such cases, autoantibodies should be sought. Antinuclear antibodies are very sensitive but non specific for SLE. Anti-double stranded DNA antibodies are specific for SLE and elevated titer should raise the suspicion of undiagnosed SLE.
Sujets
PID Serval
serval:BIB_67B7EFE86C91
PMID
Date de création
2008-01-28T11:37:42.053Z
Date de création dans IRIS
2025-05-20T22:22:09Z