Titre
A case of acute dapsone poisoning: toxicological data and review of the literature.
Type
étude de cas
Institution
Externe
Périodique
Auteur(s)
Tracqui, A.
Auteure/Auteur
Gutbub, A.M.
Auteure/Auteur
Kintz, P.
Auteure/Auteur
Mangin, P.
Auteure/Auteur
Liens vers les personnes
ISSN
0146-4760[print], 0146-4760[linking]
Statut éditorial
Publié
Date de publication
1995
Volume
19
Numéro
4
Première page
229
Dernière page/numéro d’article
235
Langue
anglais
Résumé
A case of nonfatal, acute poisoning following the ingestion of an undetermined amount of dapsone (DDS) in a 49-year-old woman is presented. The clinical features were dyspnea and deep cyanosis. Methemoglobinemia was 39.0% on admission. DDS was identified and quantitated in blood samples taken on the third day (sample A) and fifth day (sample B) in the hospital using a high-performance liquid chromatographic technique with diode-array detection. DDS concentrations were 26.99 and 8.40 micrograms/mL in samples A and B, respectively. Results are discussed in the light of an extensive review of the literature (1950-1993) available on DDS poisonings.
PID Serval
serval:BIB_53D1D6D37172
PMID
Date de création
2010-10-19T14:37:24.675Z
Date de création dans IRIS
2025-05-20T18:04:25Z