Titre
High-affinity binding of 125I-labeled mouse interferon to a specific cell surface receptor. IV. Mouse gamma interferon and cholera toxin do not compete for the common receptor site of alpha / beta interferon.
Type
article
Institution
Externe
Périodique
Auteur(s)
Aguet, M.
Auteure/Auteur
Belardelli, F.
Auteure/Auteur
Blanchard, B.
Auteure/Auteur
Marcucci, F.
Auteure/Auteur
Gresser, I.
Auteure/Auteur
Liens vers les personnes
ISSN
0042-6822
Statut éditorial
Publié
Date de publication
1982
Volume
117
Numéro
2
Première page
541
Dernière page/numéro d’article
544
Langue
anglais
Résumé
The initial step in interferon action consists of the binding to a specific high-affinity cell surface receptor. Mouse α and β interferon have been shown to share a common receptor. We now present evidence that mouse γ interferon does not compete for this receptor on mouse L 1210 and L 929 cells. Cholera toxin which binds specifically to the membrane monosialoganglioside GM1, and has been shown to inhibit interferon action, does not inhibit the specific binding of labeled mouse α/β interferon to L 1210 or L 929 cells. Conversely, mouse α/β interferon does not inhibit the specific binding of radioactive cholera toxin to L 929 cells. L 1210S cells which have a specific receptor for α/β interferon do not have a specific binding site for cholera toxin. We conclude from these studies that there is no evidence to indicate that cholera toxin and mouse α/β interferon share a common receptor.
PID Serval
serval:BIB_E28AF4913271
PMID
Date de création
2008-01-28T10:36:56.519Z
Date de création dans IRIS
2025-05-21T05:11:17Z