Titre
Intestinal permeability and inflammation in rheumatoid arthritis: effects of non-steroidal anti-inflammatory drugs
Type
article
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Périodique
Auteur(s)
Bjarnason, I.
Auteure/Auteur
Williams, P.
Auteure/Auteur
So, A.
Auteure/Auteur
Zanelli, G. D.
Auteure/Auteur
Levi, A. J.
Auteure/Auteur
Gumpel, J. M.
Auteure/Auteur
Peters, T. J.
Auteure/Auteur
Ansell, B.
Auteure/Auteur
Liens vers les personnes
Liens vers les unités
ISSN
0140-6736
Statut éditorial
Publié
Date de publication
1984-11
Volume
2
Numéro
8413
Première page
1171
Dernière page/numéro d’article
4
Notes
Journal Article --- Old month value: Nov 24
Résumé
The suggestion that the intestinal mucosa may be abnormally permeable and a site of absorption of antigens in rheumatoid arthritis was tested by the use of a 51Cr-EDTA (edetic acid) absorption test. 24 patients with rheumatoid arthritis excreted significantly more 51Cr-EDTA than did 34 controls. Intestinal permeability was normal in untreated patients but almost invariably abnormal in patients treated with non-steroidal anti-inflammatory drugs. Studies in patients with osteoarthritis showed that the permeability abnormalities were due to an effect of NSAIDs on both the proximal and the distal intestine and that the effect was systemically mediated. Indium-111-labelled leucocyte scans showed ileocaecal inflammation in 6 of 9 patients on or recently on NSAIDs. Although increased intestinal permeability does not seem to be important in the pathogenesis of rheumatoid arthritis, the administration of NSAIDs may lead to loss of intestinal integrity, thus facilitating antigenic absorption and perhaps contributing to persistence of the disease.
Sujets
PID Serval
serval:BIB_23D22B7CC1DB
PMID
Date de création
2008-01-25T07:38:57.069Z
Date de création dans IRIS
2025-05-20T15:55:16Z