Titre

Mycophenolic acid formulations in adult renal transplantation - update on efficacy and tolerability.

Type
synthèse (review)
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Périodique
Auteur(s)
Golshayan, D.
Auteure/Auteur
Pascual, M.
Auteure/Auteur
Vogt, B.
Auteure/Auteur
Liens vers les personnes
Liens vers les unités
ISSN
1176-6336
Statut éditorial
Publié
Date de publication
2009
Volume
5
Numéro
4
Première page
341
Dernière page/numéro d’article
351
Peer-reviewed
Oui
Langue
anglais
Résumé
The description more than 30 years ago of the role of de novo purine synthesis in T and B lymphocytes clonal proliferation opened the possibility for selective immunosuppression by targeting specific enzymatic pathways. Mycophenolic acid (MPA) blocks the key enzyme inosine monophosphate dehydrogenase and the production of guanosine nucleotides required for DNA synthesis. Two MPA formulations are currently used in clinical transplantation as part of the maintenance immunosuppressive regimen. Mycophenolate mofetil (MMF) was the first MPA agent to be approved for the prevention of acute rejection following renal transplantation, in combination with cyclosporine and steroids. Enteric-coated mycophenolate sodium (EC-MPS) is an alternative MPA formulation available in clinical transplantation. In this review, we will discuss the clinical trials that have evaluated the efficacy and safety of MPA in adult kidney transplantation for the prevention of acute rejection and their use in new combination regimens aiming at minimizing calcineurin inhibitor toxicity and chronic allograft nephropathy. We will also discuss MPA pharmacokinetics and the rationale for therapeutic drug monitoring in optimizing the balance between efficacy and safety in individual patients.
PID Serval
serval:BIB_267B22276362
PMID
Permalien
Date de création
2009-07-03T12:24:58.904Z
Date de création dans IRIS
2025-05-20T20:40:10Z
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Nom

BIB_267B22276362.P001.pdf

Version du manuscrit

preprint

Taille

173.59 KB

Format

Adobe PDF

PID Serval

serval:BIB_267B22276362.P001

URN

urn:nbn:ch:serval-BIB_267B222763625

Somme de contrôle

(MD5):1e6a05a66cfde62ccba9f10549ac6216