Titre
Inflammatory bowel disease in spouses and their offspring
Type
article
Institution
Externe
Périodique
Auteur(s)
Laharie, David
Auteure/Auteur
Debeugny, Stéphane
Auteure/Auteur
Peeters, Marc
Auteure/Auteur
van Gossum, André
Auteure/Auteur
Gower-Rousseau, Corinne
Auteure/Auteur
Bélaiche, Jacques
Auteure/Auteur
Fiasse, René
Auteure/Auteur
Dupas, Jean-Louis
Auteure/Auteur
Lerebours, Eric
Auteure/Auteur
Piotte, Sandrine
Auteure/Auteur
Cortot, Antoine
Auteure/Auteur
Vermeire, Séverine
Auteure/Auteur
Grandbastien, Bruno
Auteure/Auteur
Colombel, Jean-Frédéric
Auteure/Auteur
Liens vers les personnes
ISSN
0016-5085
Statut éditorial
Publié
Date de publication
2001-03
Volume
120
Numéro
4
Première page
816
Dernière page/numéro d’article
819
Langue
anglais
Résumé
BACKGROUND & AIMS: The rarity of inflammatory bowel disease (IBD) in both husband and wife is often given as an argument against an infectious origin. We registered conjugal instances of IBD in Northern France and in Belgium between 1989 and 2000. METHODS: Couples were assigned to group A if both partners had symptoms of IBD before cohabitation, to group B if one spouse had IBD before cohabitation and the other experienced first symptoms afterwards, and to group C if both partners got the disease after cohabitation. Risk of IBD was assessed in their offspring. RESULTS: Thirty conjugal instances were registered. Seventeen were concordant for Crohn’s disease and 3 for ulcerative colitis; 10 were mixed. Two belonged to group A, 6 to group B, and 22 to group C. In group C, IBD occurred in the first affected spouse an average of 9 years after cohabitation and in the second spouse an average of 8.5 years later. Group C conjugal forms were more frequent than expected by chance (P < 0.02). Fifty-four children were born to 25 couples; among them 9, of whom 4 were siblings, developed Crohn’s disease at a median age of 15 years. CONCLUSIONS: The frequency of conjugal forms of IBD suggests an etiologic role for environmental factors. Offspring of 2 affected parents have a high risk of developing IBD.
Sujets
PID Serval
serval:BIB_1C2374B0887F
PMID
Date de création
2019-07-18T11:48:31.416Z
Date de création dans IRIS
2025-05-20T15:17:33Z