Titre
JC virus-specific immune responses in human immunodeficiency virus type 1 patients with progressive multifocal leukoencephalopathy.
Type
article
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Périodique
Auteur(s)
Khanna, N.
Auteure/Auteur
Wolbers, M.
Auteure/Auteur
Mueller, N.J.
Auteure/Auteur
Garzoni, C.
Auteure/Auteur
Du Pasquier, R.A.
Auteure/Auteur
Fux, C.A.
Auteure/Auteur
Vernazza, P.
Auteure/Auteur
Bernasconi, E.
Auteure/Auteur
Viscidi, R.
Auteure/Auteur
Battegay, M.
Auteure/Auteur
Hirsch, H.H.
Auteure/Auteur
Liens vers les personnes
Liens vers les unités
ISSN
1098-5514[electronic]
Statut éditorial
Publié
Date de publication
2009
Volume
83
Numéro
9
Première page
4404
Dernière page/numéro d’article
4411
Peer-reviewed
Oui
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't Publication Status: ppublish
Résumé
Progressive multifocal leukoencephalopathy (PML) is a frequently fatal disease caused by uncontrolled polyomavirus JC (JCV) in severely immunodeficient patients. We investigated the JCV-specific cellular and humoral immunity in the Swiss HIV Cohort Study. We identified PML cases (n = 29), as well as three matched controls per case (n = 87), with prospectively cryopreserved peripheral blood mononuclear cells and plasma at diagnosis. Nested controls were matched according to age, gender, CD4(+) T-cell count, and decline. Survivors (n = 18) were defined as being alive for >1 year after diagnosis. Using gamma interferon enzyme-linked immunospot assays, we found that JCV-specific T-cell responses were lower in nonsurvivors than in their matched controls (P = 0.08), which was highly significant for laboratory- and histologically confirmed PML cases (P = 0.004). No difference was found between PML survivors and controls or for cytomegalovirus-specific T-cell responses. PML survivors showed significant increases in JCV-specific T cells (P = 0.04) and immunoglobulin G (IgG) responses (P = 0.005). IgG responses in survivors were positively correlated with CD4(+) T-cell counts (P = 0.049) and negatively with human immunodeficiency virus RNA loads (P = 0.03). We conclude that PML nonsurvivors had selectively impaired JCV-specific T-cell responses compared to CD4(+) T-cell-matched controls and failed to mount JCV-specific antibody responses. JCV-specific T-cell and IgG responses may serve as prognostic markers for patients at risk.
Sujets
PID Serval
serval:BIB_F3F95551CBD5
PMID
Open Access
Oui
Date de création
2009-11-23T23:23:31.975Z
Date de création dans IRIS
2025-05-21T06:39:54Z