Titre
Phagocytosis and inflammatory stimuli induce GM-CSF mRNA in macrophages through posttranscriptional regulation.
Type
article
Institution
Externe
Périodique
Auteur(s)
Thorens, B.
Auteure/Auteur
Mermod, J.J.
Auteure/Auteur
Vassalli, P.
Auteure/Auteur
Liens vers les personnes
ISSN
0092-8674[print], 0092-8674[linking]
Statut éditorial
Publié
Date de publication
1987-02
Volume
48
Numéro
4
Première page
671
Dernière page/numéro d’article
679
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Publication Status: ppublish
Résumé
Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF) is a powerful growth and differentiation factor which acts on hematopoietic progenitor cells and also activates differentiated granulocytes and macrophages. This study shows that mouse peritoneal macrophages can be induced to accumulate GM-CSF mRNA and to release GM-CSF by inflammatory agents (lipopolysaccharide, fetal calf serum, thioglycolate broth); phagocytosis; and adherence in the presence of fibronectin. GM-CSF mRNA accumulation, which is totally prevented by the corticosteroid dexamethasone and by interferon-gamma, is not accompanied by changes in the gene's transcriptional level. No interleukin 3 (multi-CSF) mRNA is detectable in induced macrophages. These findings have implications in the understanding of hematopoiesis and of the inflammation and repair process.
Sujets
PID Serval
serval:BIB_E0CE45C1E7A7
PMID
Date de création
2008-01-24T12:41:36.073Z
Date de création dans IRIS
2025-05-21T05:10:00Z