Titre
Viral mimicry: common mode of association with HCF by VP16 and the cellular protein LZIP.
Type
article
Institution
Externe
Périodique
Genes and Development
Auteur(s)
Freiman, R.N.
Auteure/Auteur
Herr, W.
Auteure/Auteur
Liens vers les personnes
ISSN
0890-9369[print], 0890-9369[linking]
Statut éditorial
Publié
Date de publication
1997
Volume
11
Numéro
23
Première page
3122
Dernière page/numéro d’article
3127
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, U.S. Gov't, P.H.S.
Publication Status: ppublish
Publication Status: ppublish
Résumé
Upon infection of human cells, the herpes simplex virus protein VP16 associates with the endogenous cell-proliferation factor HCF. VP16 can also associate with HCFs from invertebrates, suggesting that VP16 mimics a cellular protein whose interaction with HCF has been conserved. Here, we show that VP16 mimics the human basic leucine-zipper protein LZIP, which, through association with HCF, may control cell-cycle progression. VP16 and LZIP share a tetrapeptide motif-D/EHXY-used to associate with human HCF. The LZIP-related Drosophila protein BBF-2/dCREB-A contains this HCF-binding motif, indicating that the LZIP-HCF interaction has been conserved during metazoan evolution.
Sujets
PID Serval
serval:BIB_C62D7CA963DE
PMID
Open Access
Oui
Date de création
2009-05-04T11:03:59.550Z
Date de création dans IRIS
2025-05-21T02:25:48Z