Titre
Association of lectin pathway proteins with intra-abdominal Candida infection in high-risk surgical intensive-care unit patients. A prospective cohort study within the fungal infection network of Switzerland.
Type
article
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Périodique
Auteur(s)
Osthoff, M.
Auteure/Auteur
Wojtowicz, A.
Auteure/Auteur
Tissot, F.
Auteure/Auteur
Jørgensen, C.
Auteure/Auteur
Thiel, S.
Auteure/Auteur
Zimmerli, S.
Auteure/Auteur
Marchetti, O.
Auteure/Auteur
Khanna, N.
Auteure/Auteur
Bochud, P.Y.
Auteure/Auteur
Trendelenburg, M.
Auteure/Auteur
Fungal Infection Network of Switzerland, FUNGINOS
Auteure/Auteur
Contributrices/contributeurs
Fungal Infection Network of Switzerland, FUNGINOS
Bregenzer, T.
Conen, A.
Fankhauser, H.
Flückiger, U.
Khanna, N.
Frei, R.
Heininger, U.
Hertel, R.
Franciolli, M.
San Giovanni, O.
Dolina, M.
Rothen, M.
Dubuis, O.
Tarr, P.
Graf, S.
Fleisch, F.
Risch, M.
Ritzler, E.
Chuard, C.
Erard, V.
Fracheboud, D.
Emonet, S.
Genne, D.
Lienhardt, R.
Chave, JP.
Andreutti-Zaugg, C.
Gallusser, A.
Graber, P.
Monotti, R.
Bernasconi, E.
Krause, M.
Herzog, K.
Piso, RJ.
Schibli, U.
Bally, F.
Troillet, N.
Tissière, L.
Boggian, K.
Bruderer, T.
Gubler, J.
Eich, G.
Berger, C.
Groupes de travail
Fungal Infection Network of Switzerland (FUNGINOS)
Liens vers les personnes
Liens vers les unités
ISSN
1532-2742
Statut éditorial
Publié
Date de publication
2016
Volume
72
Numéro
3
Première page
377
Dernière page/numéro d’article
385
Peer-reviewed
Oui
Langue
anglais
Résumé
OBJECTIVES: Human studies on the role of mannose-binding lectin (MBL) in patients with invasive candidiasis have yielded conflicting results. We investigated the influence of MBL and other lectin pathway proteins on Candida colonization and intra-abdominal candidiasis (IAC) in a cohort of high-risk patients.
METHODS: Prospective observational cohort study of 89 high-risk intensive-care unit (ICU) patients. Levels of lectin pathway proteins at study entry and six MBL2 single-nucleotide polymorphisms were analyzed by sandwich-type immunoassays and genotyping, respectively, and correlated with development of heavy Candida colonization (corrected colonization index (CCI) ≥0.4) and occurrence of IAC during a 4-week period.
RESULTS: Within 4 weeks after inclusion a CCI ≥0.4 and IAC was observed in 47% and 38% of patients respectively. Neither serum levels of MBL, ficolin-1, -2, -3, MASP-2 or collectin liver 1 nor MBL2 genotypes were associated with a CCI ≥0.4. Similarly, none of the analyzed proteins was found to be associated with IAC with the exception of lower MBL levels (HR 0.74, p = 0.02) at study entry. However, there was no association of MBL deficiency (<0.5 μg/ml), MBL2 haplo- or genotypes with IAC.
CONCLUSION: Lectin pathway protein levels and MBL2 genotype investigated in this study were not associated with heavy Candida colonization or IAC in a cohort of high-risk ICU patients.
METHODS: Prospective observational cohort study of 89 high-risk intensive-care unit (ICU) patients. Levels of lectin pathway proteins at study entry and six MBL2 single-nucleotide polymorphisms were analyzed by sandwich-type immunoassays and genotyping, respectively, and correlated with development of heavy Candida colonization (corrected colonization index (CCI) ≥0.4) and occurrence of IAC during a 4-week period.
RESULTS: Within 4 weeks after inclusion a CCI ≥0.4 and IAC was observed in 47% and 38% of patients respectively. Neither serum levels of MBL, ficolin-1, -2, -3, MASP-2 or collectin liver 1 nor MBL2 genotypes were associated with a CCI ≥0.4. Similarly, none of the analyzed proteins was found to be associated with IAC with the exception of lower MBL levels (HR 0.74, p = 0.02) at study entry. However, there was no association of MBL deficiency (<0.5 μg/ml), MBL2 haplo- or genotypes with IAC.
CONCLUSION: Lectin pathway protein levels and MBL2 genotype investigated in this study were not associated with heavy Candida colonization or IAC in a cohort of high-risk ICU patients.
PID Serval
serval:BIB_45733C41DBF6
PMID
Open Access
Oui
Date de création
2016-01-08T10:31:19.142Z
Date de création dans IRIS
2025-05-20T14:41:26Z