Titre
First Report of Edge Vascular Response at 12 Months of Magmaris, A Second-Generation Drug-Eluting Resorbable Magnesium Scaffold, Assessed by Grayscale Intravascular Ultrasound, Virtual Histology, and Optical Coherence Tomography. A Biosolve-II Trial Sub-Study.
Type
article
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Périodique
Auteur(s)
Hideo-Kajita, A.
Auteure/Auteur
Garcia-Garcia, H.M.
Auteure/Auteur
Haude, M.
Auteure/Auteur
Joner, M.
Auteure/Auteur
Koolen, J.
Auteure/Auteur
Ince, H.
Auteure/Auteur
Abizaid, A.
Auteure/Auteur
Toelg, R.
Auteure/Auteur
Lemos, P.A.
Auteure/Auteur
von Birgelen, C.
Auteure/Auteur
Christiansen, E.H.
Auteure/Auteur
Wijns, W.
Auteure/Auteur
Neumann, F.J.
Auteure/Auteur
Kaiser, C.
Auteure/Auteur
Eeckhout, E.
Auteure/Auteur
Teik, L.S.
Auteure/Auteur
Escaned, J.
Auteure/Auteur
Azizi, V.
Auteure/Auteur
Kuku, K.O.
Auteure/Auteur
Ozaki, Y.
Auteure/Auteur
Dan, K.
Auteure/Auteur
Waksman, R.
Auteure/Auteur
Liens vers les personnes
Liens vers les unités
ISSN
1878-0938
Statut éditorial
Publié
Date de publication
2019-05
Volume
20
Numéro
5
Première page
392
Dernière page/numéro d’article
398
Peer-reviewed
Oui
Langue
anglais
Notes
Publication types: Clinical Trial ; Journal Article ; Multicenter Study
Publication Status: ppublish
Publication Status: ppublish
Résumé
The edge vascular response (EVR) remains unknown in second generation drug-eluting Resorbable Magnesium Scaffold (RMS), such as Magmaris. The aim of the study was to evaluate tissue modifications in the RMS edges over time, assessed by different invasive imaging modalities.
The patients treated with the device were assessed by optical coherence tomography (OCT), grayscale intravascular ultrasound (IVUS), and virtual histology IVUS at baseline and 12 months. The EVR study performed a segment- and frame-level analysis of the 5 mm segments proximal and distal of the actual RMS.
The segment-level grayscale IVUS (n = 10), virtual histology IVUS (n = 10), and OCT (n = 18) analysis did not show any significant changes after 12 months, except for a fibrous plaque area (FPA) reduction of 0.5mm <sup>2</sup> (p = 0.017) in the proximal segment compared to baseline. In the frame-level analysis, IVUS evaluation revealed a vessel area decreased 2.80 ± 1.43 mm <sup>2</sup> (p = 0.012) and 2.49 ± 1.53 mm <sup>2</sup> (p = 0.022) in 2 proximal frames. This was accompanied by plaque area reduction of 0.88 ± 0.70 mm <sup>2</sup> (p = 0.048) and a FPA decreased by 0.63 ± 0.48 mm <sup>2</sup> (p = 0.004) in one proximal frame. In 1 distal frame, there was a dense calcium area reduction of 0.10 ± 0.12 mm <sup>2</sup> (p = 0.045), FPA and fibrous fatty plaque increased 0.54 ± 0.53 mm <sup>2</sup> (p = 0.023) and 0.17 ± 0.16 mm <sup>2</sup> (p = 0.016), respectively. By OCT, there was a lumen area decrease of 0.76 ± 1.51 mm <sup>2</sup> (p = 0.045) in a distal frame.
At 12 months, Magmaris EVR assessment does not show overall significant changes, except for a fibrous plaque area reduction in the proximal segment. This could be translated as a benign healing process at the edges of the RMS.
The edge vascular response (EVR) remains unknown in second generation drug-eluting absorbable metal scaffolds (RMS), such as Magmaris. Patients treated with the device were assessed by multi invasive imaging modalities [i.e. optical coherence tomography (OCT), grayscale intravascular ultrasound (IVUS), and virtual histology IVUS] evaluating the tissue changes over time in the segment- and frame-level analysis of the 5 mm segments proximal and distal of the actual RMS. As a result, after 12 months, Magmaris EVR assessment does not show overall significant changes, except for a fibrous plaque area reduction in the proximal segment, translating a benign healing process at the edges of the RMS.
The patients treated with the device were assessed by optical coherence tomography (OCT), grayscale intravascular ultrasound (IVUS), and virtual histology IVUS at baseline and 12 months. The EVR study performed a segment- and frame-level analysis of the 5 mm segments proximal and distal of the actual RMS.
The segment-level grayscale IVUS (n = 10), virtual histology IVUS (n = 10), and OCT (n = 18) analysis did not show any significant changes after 12 months, except for a fibrous plaque area (FPA) reduction of 0.5mm <sup>2</sup> (p = 0.017) in the proximal segment compared to baseline. In the frame-level analysis, IVUS evaluation revealed a vessel area decreased 2.80 ± 1.43 mm <sup>2</sup> (p = 0.012) and 2.49 ± 1.53 mm <sup>2</sup> (p = 0.022) in 2 proximal frames. This was accompanied by plaque area reduction of 0.88 ± 0.70 mm <sup>2</sup> (p = 0.048) and a FPA decreased by 0.63 ± 0.48 mm <sup>2</sup> (p = 0.004) in one proximal frame. In 1 distal frame, there was a dense calcium area reduction of 0.10 ± 0.12 mm <sup>2</sup> (p = 0.045), FPA and fibrous fatty plaque increased 0.54 ± 0.53 mm <sup>2</sup> (p = 0.023) and 0.17 ± 0.16 mm <sup>2</sup> (p = 0.016), respectively. By OCT, there was a lumen area decrease of 0.76 ± 1.51 mm <sup>2</sup> (p = 0.045) in a distal frame.
At 12 months, Magmaris EVR assessment does not show overall significant changes, except for a fibrous plaque area reduction in the proximal segment. This could be translated as a benign healing process at the edges of the RMS.
The edge vascular response (EVR) remains unknown in second generation drug-eluting absorbable metal scaffolds (RMS), such as Magmaris. Patients treated with the device were assessed by multi invasive imaging modalities [i.e. optical coherence tomography (OCT), grayscale intravascular ultrasound (IVUS), and virtual histology IVUS] evaluating the tissue changes over time in the segment- and frame-level analysis of the 5 mm segments proximal and distal of the actual RMS. As a result, after 12 months, Magmaris EVR assessment does not show overall significant changes, except for a fibrous plaque area reduction in the proximal segment, translating a benign healing process at the edges of the RMS.
Sujets
PID Serval
serval:BIB_33BDF5807565
PMID
Date de création
2019-06-03T07:24:25.172Z
Date de création dans IRIS
2025-05-20T16:52:12Z