Titre
Human inhalation exposure to iron oxide particles
Type
synthèse (review)
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Périodique
BioNanoMaterials
Auteur(s)
Lewinski, Nastassja
Auteure/Auteur
Graczyk, Halshka
Auteure/Auteur
Riediker, Michael
Auteure/Auteur
Liens vers les personnes
Liens vers les unités
ISSN
2193-066X
Statut éditorial
Publié
Date de publication
2013
Volume
14
Numéro
1-2
Première page
5
Dernière page/numéro d’article
23
Peer-reviewed
Oui
Langue
anglais
Notes
Le DOI est erroné sur le site de l'éditeur (De Gruyter)
Résumé
In the past decade, many studies have been conducted to determine the health effects induced by exposure to engineered nanomaterials (NMs). Specifically for exposure via inhalation, numerous in vitro and animal in vivo inhalation toxicity studies on several types of NMs have been published. However, these results are not easily extrapolated to judge the effects of inhaling NMs in humans, and few published studies on the human response to inhalation of NMs exist. Given the emergence of more industries utilizing iron oxide nanoparticles as well as more nanomedicine applications of superparamagnetic iron oxide nanoparticles (SPIONs), this review presents an overview of the inhalation studies that have been conducted in humans on iron oxides. Both occupational exposure studies on complex iron oxide dusts and fumes, as well as human clinical studies on aerosolized, micron-size iron oxide particles are discussed. Iron oxide particles have not been described to elicit acute inhalation response nor promote lung disease after chronic exposure. The few human clinical studies comparing inhalation of fine and ultrafine metal oxide particles report no acute changes in the health parameters measured. Taken together existing evidence suggests that controlled human exposure to iron oxide nanoparticles, such as SPIONs, could be conducted safely.
PID Serval
serval:BIB_D91F54A24F3E
Open Access
Oui
Date de création
2013-10-03T10:56:11.946Z
Date de création dans IRIS
2025-05-21T02:31:46Z
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Nom
REF.pdf
Version du manuscrit
published
Taille
411.07 KB
Format
Adobe PDF
PID Serval
serval:BIB_D91F54A24F3E.P001
URN
urn:nbn:ch:serval-BIB_D91F54A24F3E9
Somme de contrôle
(MD5):7a71cb2cd21297f9bf66bcab90e1b675